Evidence map›Paper›PMID 29143219›Full record

ArticlePflugers Archiv : European journal of physiology2018

Glutamatergic, GABAergic, and endocannabinoid neurotransmissions within the dorsal hippocampus modulate the cardiac baroreflex function in rats.

Nilson Carlos Ferreira-Junior, Davi Campos Lagatta, Leonardo Barbosa Moraes Resstel

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. D-Serine: A Cross Species Review of Safety.Frontiers in psychiatry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nilson Carlos Ferreira-JuniorDepartment of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 3900, Bandeirantes Avenue, Monte Alegre, Ribeirao Preto, SP, 14049-900, Brazil.
Davi Campos LagattaDepartment of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 3900, Bandeirantes Avenue, Monte Alegre, Ribeirao Preto, SP, 14049-900, Brazil.
Leonardo Barbosa Moraes ResstelDepartment of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 3900, Bandeirantes Avenue, Monte Alegre, Ribeirao Preto, SP, 14049-900, Brazil. leoresstel@fmrp.usp.br.
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BR

Funding

CNPq 305996/2008-8CNPq 470042/2009-5FAPESP 2011/07332-3FAPESP 2011/19494-8
6 · The paper itself

Abstract

The dorsal hippocampus (DH) is involved in the modulation of the cardiac baroreflex function. There is a wide expression of the NMDA and AMPA/Kainate receptors within the DH. Glutamate administration into the DH triggers both tachycardia and pressor responses. Moreover, GABAergic interneurons and endocannabinoid system play an important role in modulation of the activity of glutamatergic neurons within the DH. Therefore, the present work aimed to evaluate the involvement of the glutamatergic, GABAergic, and endocannabinoid neurotransmissions within the DH in cardiac baroreflex function in rats. We have used the technique of vasoactive drugs infusion to build both sigmoidal curves and linear regressions to analyze the cardiac baroreflex function. Bilateral injection into the DH of DL-AP7, a NMDA receptor antagonist (10 or 50 nmol/500 nL), or NBQX, an AMPA/Kainate antagonist (100 nmol/ 500 nL), reduced the cardiac baroreflex function. On the other hand, bilateral injection of Bicuculline, a GABA

Indexed as

BaroreflexAnimalsCannabinoid Receptor AntagonistsExcitatory Amino Acid AntagonistsGABA AntagonistsHeartHippocampusMaleRatsRats, WistarReceptors, CannabinoidReceptors, GABAReceptors, GlutamateSynaptic TransmissionCannabinoid Receptor AntagonistsExcitatory Amino Acid AntagonistsGABA AntagonistsReceptors, CannabinoidReceptors, GABAReceptors, GlutamateAMPA/Kainate receptorsAutonomic nervous systemBaroreflexCannabinoid receptorEndocannabinoidsGABAA receptorNMDA receptor

Identifiers

PMID29143219
OpenAlexW2768811819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.