Evidence map›Paper›PMID 29143095›Full record

ArticleSocial psychiatry and psychiatric epidemiology2018

Areca nut chewing is associated with common mental disorders: a population-based study.

Tzu-Yu Lin, Huan-Cheng Chang, Kuang-Hung Hsu

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In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Betel-quid Use Is Associated with Depression.International journal of medical sciences · 2026
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  4. Retention in Community Health Screening among Taiwanese Adults: A 9-Year Prospective Cohort Study.International journal of environmental research and public health · 2022
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  6. Review
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4 · The record

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5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tzu-Yu LinHealthy Aging Research Centre, Chang Gung University, Taoyuan, Taiwan.
Huan-Cheng ChangDivision of Family Medicine, Taiwan Landseed Hospital, Taoyuan, Taiwan.
Kuang-Hung HsuHealthy Aging Research Centre, Chang Gung University, Taoyuan, Taiwan. khsu@mail.cgu.edu.tw.ORCID 0000-0003-2642-7689
Chang Gung University · TWChang Gung University of Science and Technology · TW

Funding

Healthy Aging Research Centre, Chang Gung University EMRPD 1D0911, EMRPD 1E1691, EMRPD 1F0301, EMRPD 1G0221Ministry of Science and Technology, Taiwan CMRPD390041, CMRPD390042, and CMRPD390043Wang Jhan-Yang Charitable Trust Fund WJY 2017-HR-01
6 · The paper itself

Abstract

introductionForms of habitual substance use including cigarette smoking and alcohol consumption have been documented as risk factors of common mental disorders (CMDs). The effects of areca nut chewing on biophysiological tests, metabolic syndromes, and liver function have been reported previously; however, the relationship between areca nut chewing and CMDs remains unclear. This study examined the association between areca nut chewing and CMDs and explored the relationships between areca nut chewing and biophysiological indicators.

methodsA total of 4477 community dwellers who had enrolled in a cohort study and participated in health examinations in 2 consecutive years were selected for analysis in the present study. The community cohort was established in northern Taiwan during 2006-2012. The Chinese health questionnaire (CHQ-12) was used as a self-reported screening instrument to assess the potential for developing psychotic mental disorders (CHQ-12 score ≥ 3) among the community residents. Biophysiological tests performed 1 year before CMD assessment were analyzed to examine the causal pathways between areca nut chewing and CMDs. Multiple logistic regression and stratified analyses were performed.

resultsA total of 18.23% of the participants were diagnosed as having CMDs. Factors including areca nut chewing [odds ratio (OR) 1.828; 95% confidence interval (CI) 1.165-2.869], sex (women; OR 1.828; 95% CI 1.165-2.869), age (30-49; OR 1.302; 95% CI 1.073-1.579), and socioeconomic status (lower status; OR 1.373; 95% CI 1.084-1.738) were associated with CMDs in a multiple logistic regression model. Areca nut chewers exhibited significantly more triglycerides (220.04 vs. 124.16 mg/dL) and white blood cells (65.17 102/μL vs. 60.36 102/μL) and significantly higher diastolic blood pressure (78.83 vs. 75.84 mmHg) and glutamic oxaloacetic transaminase (30.30 vs. 25.45 U/L) than did the controls.

conclusionsThis study demonstrated the association between areca nut chewing and CMDs and its effects on biophysiological tests in a community-based population in Taiwan. The findings suggest the existence of mechanistic effects of areca nut chewing on CMDs exerted through multiple pathways that may interact with pre-existing biophysiological abnormalities. Lifestyle variables should be considered for the prevention and management of mental disorders in the future.

Indexed as

ArecaMasticationNutsAdultAge FactorsAsian PeopleCohort StudiesFemaleHumansLogistic ModelsMaleMental DisordersMiddle AgedMultivariate AnalysisOdds RatioRisk FactorsAreca nut chewingBiophysiological testsCommon mental disordersCommunity cohortPopulation-based study

Identifiers

PMID29143095
OpenAlexW2770546856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.