ArticleKidney international reports2017
Low Urinary Creatinine Excretion Is Associated With Self-Reported Frailty in Patients With Advanced Chronic Kidney Disease.
Article in Kidney international reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Association between the "Timed Up and Go Test" at transplant evaluation and outcomes after kidney transplantation.Clinical transplantation · 2018Trial
- Malnutrition-inflammation-fluid overload complex syndrome and all-cause mortality in patients undergoing hemodialysisRenal failure · 2025Article
- Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Association Between Dietary Potassium Intake Estimated From Multiple 24-Hour Urine Collections and Serum Potassium in Patients With CKD.Kidney international reports · 2023Article
- Association of the modified creatinine index with muscle strength and mortality in patients undergoing hemodialysis.Renal failure · 2022Article
- A Novel Application of Serum Creatinine and Cystatin C to Predict Sarcopenia in Advanced CKD.Frontiers in nutrition · 2022Article
- Clinical and Dietary Determinants of Muscle Mass in Patients with Type 2 Diabetes: Data from the Diabetes and Lifestyle Cohort Twente.Journal of clinical medicine · 2021Article
- Creatine homeostasis and protein energy wasting in hemodialysis patients.Journal of translational medicine · 2021Article
- Measuring Muscle Mass and Strength in Obesity: a Review of Various Methods.Obesity surgery · 2021Review
- Muscle mass determined from urinary creatinine excretion rate, and muscle performance in renal transplant recipients.Journal of cachexia, sarcopenia and muscle · 2019Article
- Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review.Nutrients · 2019Review
- Lower body mass index and mortality in older adults starting dialysis.Scientific reports · 2018Article
- Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFrailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are lacking. We first defined low UCrE and studied correlates of low UCrE, and subsequently studied cross-sectional associations of frailty with low UCrE in patients with advanced CKD.
methodsA total of 2748 healthy individuals of the general population-based PREVEND study were included to define low UCrE (UCrE indexed for height, below the age- and sex-specific 5th percentile of the distribution). Frailty was defined using a modification of the Fried frailty phenotype. In a CKD population that included 320 and 967 participants of the PREPARE-2 and NECOSAD studies, respectively, cross-sectional associations of self-reported frailty, the individual components that define self-reported frailty, and frailty-associated variables with low UCrE were evaluated using multivariate logistic and linear regression models.
resultsLow UCrE was found in 38% of the CKD patients. A lower glomerular filtration rate was strongly associated with low UCrE. Self-reported frailty (adjusted odds ratio: 2.19; 95% confidence interval: 1.28-3.77) and the individual components were associated with low UCrE, independent of comorbidities. The frailty-associated variables hemoglobin and albumin were inversely associated with low UCrE, and parathyroid hormone was positively associated with low UCrE. DISCUSSION: Lower kidney function is a strong correlate of low UCrE and self-reported frailty, and the individual frailty components are associated with low UCrE as well, independent of comorbidities.
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