Evidence map›Paper›PMID 29142973›Full record

ArticleKidney international reports2017

Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein.

Dorota Rowczenio, Maria Stensland, Gustavo A de Souza, Erik H Strøm, Janet A Gilbertson, Graham Taylor, Nigel Rendell, Shane Minogue, Yvonne A Efebera, Helen J Lachmann and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pathogenesis and kidney prognosis of renal amyloidosis.Cellular and molecular life sciences : CMLS · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Fibrinogen αC domain: Its importance in physiopathology.Research and practice in thrombosis and haemostasis · 2019
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Dorota RowczenioNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Maria StenslandNorwegian Work Group of Amyloidosis, Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Gustavo A de SouzaNorwegian Work Group of Amyloidosis, Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Erik H StrømNorwegian Work Group of Amyloidosis, Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Janet A GilbertsonNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Graham TaylorNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Nigel RendellNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Shane MinogueLipid and Membrane Biology Group, Division of Medicine, UCL, London, UK.
Yvonne A EfeberaDivision of Hematology, Department of Internal Medicine, The Ohio State University, Ohio, USA.
Helen J LachmannNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Ashutosh D WechalekarNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Philip N HawkinsNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Ketil R HeimdalDepartment of Genetics, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Kristian SelvigDepartment of Internal Medicine, Drammen Hospital, Drammen, Norway.
Inger K LægreidDepartment of Nephrology, St. Olavs Hospital, Trondheim, Norway.
Nathalie DemoulinDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Selda AydinInstitut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Belgium.
Julian D GillmoreNational Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, UCL, London, UK.
Tale N WienNorwegian Work Group of Amyloidosis, Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
University College London · GBOslo University Hospital · NOUCLouvain · BEDrammen Hospital · NOSt Olav's University Hospital · NOThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (

methodsSix patients presented with proteinuria, hypertension, and/or lower limb edema and underwent detailed clinical and laboratory investigations.

resultsA novel DISCUSSION: We report 6 novel mutations in the

Indexed as

anti-GBM glomerulonephritisend-stage renal disease (ESRD)fibrinogen A alpha chainhereditary renal amyloidosismass spectrometry-based proteomics

Identifiers

PMID29142973
PMCPMC5678610
OpenAlexW2553769867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.