Evidence map›Paper›PMID 29142825›Full record

ArticleMetabolic engineering communications2016

Creating metabolic demand as an engineering strategy in

Till Tiso, Petra Sabelhaus, Beate Behrens, Andreas Wittgens, Frank Rosenau, Heiko Hayen, Lars Mathias Blank

Open access · goldAbstract read
In one paragraph

Article in Metabolic engineering communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Review
  3. Heterologous rhamnolipid biosynthesis byApplied and environmental microbiology · 2025
    Article
  4. Review
  5. Recent fermentation developments for improved rhamnolipid production.Applied microbiology and biotechnology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. DoE-based medium optimization for improved biosurfactant production withFrontiers in bioengineering and biotechnology · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Coupling an ElectroactiveMicroorganisms · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Till TisoiAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
Petra SabelhausiAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
Beate BehrensInstitute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, D-48149 Münster, Germany.
Andreas WittgensUlm Center for Peptide Pharmaceuticals, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
Frank RosenauUlm Center for Peptide Pharmaceuticals, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
Heiko HayenInstitute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, D-48149 Münster, Germany.
Lars Mathias BlankiAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
RWTH Aachen University · DEUniversität Ulm · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic engineering of microbial cell factories for the production of heterologous secondary metabolites implicitly relies on the intensification of intracellular flux directed toward the product of choice. Apart from reactions following peripheral pathways, enzymes of the central carbon metabolism are usually targeted for the enhancement of precursor supply. In

Indexed as

BiosurfactantCCM, central carbon metabolismCDW, cell dry weightDriven by demandED pathway, Entner-Doudoroff pathwayFBA, flux balance analysisHAA, hydroxyalkanoyloxy-alkanoic acidLPS, lipopolysaccharideMetabolic controlNon-pathogenic PseudomonasPHA, polyhydroxyalkanoatePP pathway, pentose phosphate pathwayRhamnolipidRL, rhamnolipidSynthetic promoterTCA, tricarboxylic acid

Identifiers

PMID29142825
PMCPMC5678820
OpenAlexW2484743999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.