ArticleChemical science2015
Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 123 citations in OpenAlex.
- Synthesis of Okaramine M, Its Conversion to Amauromines, and Concise Bidirectional and Biomimetic Total Synthesis of Amauromines.Organic letters · 2025Article
- Nickel(II)-Catalyzed Formal [3+2] Cycloadditions between Indoles and Donor-Acceptor Cyclopropanes.Molecules (Basel, Switzerland) · 2024Article
- Diversity-Oriented Catalytic Asymmetric Dearomatization of Indoles with o-Quinone Diimides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols.Chemical science · 2022Article
- Enantioselective Allylation of Alkenyl Boronates Promotes a 1,2-Metalate Rearrangement with 1,3-Diastereocontrol.Journal of the American Chemical Society · 2021Article
- Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization under mild conditions.Chemical science · 2020Article
- Iridium-Catalyzed Enantioselective Intermolecular Indole C2-Allylation.Angewandte Chemie (International ed. in English) · 2020Article
- Recent metal-catalysed approaches for the synthesis of cyclopenta[RSC advances · 2018Review
- Cobalt-catalysed reductive C-H alkylation of indoles using carboxylic acids and molecular hydrogen.Chemical science · 2017Article
- Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis.Journal of the American Chemical Society · 2017Article
- Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding.Chemical science · 2016Article
- On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan.Chemical science · 2016Article
- Enantioselective γ-Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement.Journal of the American Chemical Society · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An Ir-catalyzed asymmetric allylic alkylation of 3-substituted indoles is reported. The reaction provides indoline products containing multiple contiguous stereocenters with high site-, regio-, diastereo- and enantioselectivities in one step from a wide range of readily available starting materials. The key to this method is the high level of diastereocontrol enabled by an iridium catalyst derived from a
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Registered trials
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