ArticleThe International journal of angiology : official publication of the International College of Angiology, Inc2017
Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans.
Article in The International journal of angiology : official publication of the International College of Angiology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- The Angiography Pattern of Buerger's Disease: Challenges and Recommendations.Journal of clinical medicine · 2025Review
- Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans.Genes · 2023Article
- The Association of HLA-A, B and DRB1 with Buerger's Disease.Reports of biochemistry & molecular biology · 2019Article
- Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review.Iranian journal of basic medical sciences · 2019Review
- Vaso-nervorumitis: responsible for pain in Buerger's disease?International medical case reports journal · 2019Article
- Unexpected inflammation in the sympathetic ganglia in thromboangiitis obliterans: more likely sterile or infectious induced inflammation?Clinical and molecular allergy : CMA · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to inspect more closely the microscopic and molecular sympathetic ganglia histology in thromboangiitis obliterans (TAO). The paraffin block and frozen RNAlater-treated tissue of the lumbar sympathetic ganglia of 19 TAO Caucasian male patients were evaluated. The gene expression of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) markers in the frozen RNAlater-treated sympathetic ganglia tissues were evaluated by real-time polymerase chain reaction. Unexpectedly, lymphocyte infiltration was observed in all of the histological sections, ranging from scattered to moderate lymphocyte infiltration. In seven patients, five of them underwent below-knee amputation, neutrophil infiltration was observed in addition to lymphocyte infiltration. The gene expression of the CD8 marker in all of the samples with the expression of CD4 markers in only four tissue samples was demonstrated. The expression of CD8 in comparison to CD4 was approximately 4.37-fold changes using Pfaffle method. It appears that inflammation of the sympathetic ganglia plays a role in the pathophysiology of TAO and its outcome. Sympathetic ganglia inflammation may be responsible for general vasoconstriction, vascular inflammation, and the increased risk of thrombotic events, by activating the platelets. The dominant infiltration of T cytotoxic lymphocytes and neutrophils in sympathetic ganglia may probably support the idea of possible intracellular infectious pathogen trigger for TAO and consequently infiltration of pathogen-specific T cells into the sympathetic ganglia in TAO.
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Registered trials
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