ArticlePharmacognosy magazine2017
Reversible Testicular Toxicity of Piperine on Male Albino Rats.
Article in Pharmacognosy magazine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Research Progress on the Pyroptosis Mechanism and Related Active Ingredients of Natural Drugs in Spinal Cord Injury.International journal of general medicine · 2026Review
- Fenofibrate ameliorated atorvastatin and piperine-induced ROS mediated reproductive toxicity in male Wistar rats.Toxicology reports · 2025Article
- An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer.Cancers · 2024Review
- The attenuation effect of low piperinePharmaceutical biology · 2022Article
- A Comparative study on the effects of Yaji (Suya Meat sauce) and its spice constituents on the male reproductive profile of adult male Sprague Dawley rats.JBRA assisted reproduction · 2021Article
- Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus.Foods (Basel, Switzerland) · 2021Review
- Effects of monosodium glutamate on testicular structural and functional alterations induced by quinine therapy in rat: An experimental study.International journal of reproductive biomedicine · 2021Article
- Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives.Frontiers in pharmacology · 2021Review
- Testis Toxicants: Lesson from Traditional Chinese Medicine (TCM).Advances in experimental medicine and biology · 2021Article
- Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease.Frontiers in pharmacology · 2019Review
- Diverged Effects of Piperine on Testicular Development: Stimulating Leydig Cell Development but Inhibiting Spermatogenesis in Rats.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPiperine was widely used in traditional medicine for inducing sterility and abortion.
objectiveTo evaluate the effect of the piperine on testis of male albino rats. MATERIALS AND
methodsAdult male rats were divided into four groups (
resultsPiperine significantly decreased the reproductive organ weights in groups ED and E4D. Piperine induced hormonal imbalance by altering the serum levels of follicle-stimulating hormone, luteinizing hormone, sex hormone binding globulin, serum, and testicular testosterone in groups ED and E4D. Furthermore, piperine decreased the activity of germ cell markers and Leydig cellular steroidogenic enzymes in the groups ED and E4D after 60 days. All the above-altered values returned to normal levels after withdrawal period. Histopathological findings also supported the above findings.
conclusionFrom the above data, it can be concluded that piperine could be a good lead molecule for the development of reversible oral male contraceptive. SUMMARY: Piperine was employed for the contraceptive purposes in traditional medicinePiperine significantly impaired the spermatogenesis by decreasing the testicular hormone synthesis in groups ED and E4DPiperine disrupted the testicular antioxidant system by promoting the ROS production and hydroxyl radical generation in rat testis in groups ED and E4DHistopathological evidence supported the disruption of spermatogenesis by piperineAll the effects of piperine after the treatment period (i.e. 60 days) were back to normal after the withdrawal period (i.e., after 120 days).
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