ReviewSpinal cord2018
Neural pathways for colorectal control, relevance to spinal cord injury and treatment: a narrative review.
Review in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06205446 (Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction: Impact on Gastrointestinal and Psychological Symptoms as Well as Autonomic Nervous System
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury.Cellular and molecular neurobiology · 2025Review
- Non-occlusive Mesenteric Ischemia Following Severe Traumatic Brain Injury: A Case Report.Cureus · 2025Article
- Recent Developments in On-Demand Voiding Therapies.The Journal of pharmacology and experimental therapeutics · 2024Review
- Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats.The Journal of pharmacology and experimental therapeutics · 2024Article
- Physiology of lower gastrointestinal tract.Alimentary pharmacology & therapeutics · 2024Review
- Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre.The Journal of physiology · 2023Article
- Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients.Scientific reports · 2023Article
- Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat.Disease models & mechanisms · 2023Article
- Roles of Heart Rate Variability in Assessing Autonomic Nervous System in Functional Gastrointestinal Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation.Scientific reports · 2022Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- The Effect of Non-invasive Spinal Cord Stimulation on Anorectal Function in Individuals With Spinal Cord Injury: A Case Series.Frontiers in neuroscience · 2022Article
- Modulation of the autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction.Frontiers in neuroscience · 2022Article
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Effects of highly selective sympathectomy on neurogenic bowel dysfunction in spinal cord injury rats.Scientific reports · 2021Article
- Review: Pelvic nerves - from anatomy and physiology to clinical applications.Translational neuroscience · 2021Review
- Optimizing Autonomic Function Analysis via Heart Rate Variability Associated With Motor Activity of the Human Colon.Frontiers in physiology · 2021Article
- Diet in neurogenic bowel management: A viewpoint on spinal cord injury.World journal of gastroenterology · 2020Review
- On the nature of high-amplitude propagating pressure waves in the human colon.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- The Dual Nature of Onuf's Nucleus: Neuroanatomical Features and Peculiarities, in Health and Disease.Frontiers in neuroanatomy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designNarrative review.
objectivesThe purpose is to review the organisation of the nerve pathways that control defecation and to relate this knowledge to the deficits in colorectal function after SCI.
methodsA literature review was conducted to identify salient features of defecation control pathways and the functional consequences of damage to these pathways in SCI.
resultsThe control pathways for defecation have separate pontine centres under cortical control that influence defecation. The pontine centres connect, separately, with autonomic preganglionic neurons of the spinal defecation centres and somatic motor neurons of Onuf's nucleus in the sacral spinal cord. Organised propulsive motor patterns can be generated by stimulation of the spinal defecation centres. Activation of the somatic neurons contracts the external sphincter. The analysis aids in interpreting the consequences of SCI and predicts therapeutic strategies.
conclusionsAnalysis of the bowel control circuits identifies sites at which bowel function may be modulated after SCI. Colokinetic drugs that elicit propulsive contractions of the colorectum may provide valuable augmentation of non-pharmacological bowel management procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.