Evidence map›Paper›PMID 29142275›Full record

ArticleScientific reports2017

NF-κB Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death.

Amrendra Kumar, Laura E Gordy, Jelena S Bezbradica, Aleksandar K Stanic, Timothy M Hill, Mark R Boothby, Luc Van Kaer, Sebastian Joyce

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Amrendra KumarVeterans Administration Tennessee Valley Healthcare System, Nashville, USA.
Laura E GordyDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jelena S BezbradicaDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Aleksandar K StanicDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-1946-6436
Timothy M HillDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Mark R BoothbyDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Luc Van KaerDepartment of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sebastian JoyceVeterans Administration Tennessee Valley Healthcare System, Nashville, USA. sebastian.joyce@vanderbilt.edu.
Vanderbilt University · USUnited States Military Academy · USUniversity of Wisconsin–Madison · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Immunobiology of Blood and Vascular Systems Training ProgramT32HL069765 · NHLBI · VANDERBILT UNIVERSITY · PI HAWIGER, JACK J · 2002 to 2016
$6.5M
Signaling Functions of the Tumor Suppressor CYLDR01AI064639 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUN, SHAO-CONG · 2006 to 2014
$3.6M
MOLECULAR BASIS OF CDLDL AND NATURAL T CELL FUNCTIONR01AI042284 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 1998 to 2013
$3.1M
Roles of rictor in mTOR signaling, differentiation & immune memory via Akt & PKCR01HL106812 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOOTHBY, MARK R · 2011 to 2018
$3.1M
Regulation of T-cell function and autoimmune inflammation by deubiquitinases.R37AI064639 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUN, SHAO-CONG · 2015 to 2021
$2.8M
Molecular Basis of iNKT Cell Ontogeny and FunctionR01AI061721 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 2006 to 2010
$2.1M
BcI-2 family in T lymphocyte homeostasisR01AI074754 · NIAID · DUKE UNIVERSITY · PI HE, YOU-WEN · 2009 to 2013
$1.9M
Mechanisms and consequences of iNKT cell anergyR01AI070305 · NIAID · VANDERBILT UNIVERSITY · PI VAN KAER, LUC · 2007 to 2011
$1.9M
Interleukin 4 Regulation of LymphocytesR01AI068149 · NIAID · VANDERBILT UNIVERSITY · PI BOOTHBY, MARK R · 2006 to 2010
$1.8M
CELLULAR AND MOLECULAR MICROBIOLOGY TRAINING PROGRAMT32AI007611 · NIAID · VANDERBILT UNIVERSITY · PI HAWIGER, JACK J · 1999 to 2010
$1.6M
BLRD VA I01 BX001444NCI NIH HHS P30 CA068485NHLBI NIH HHS R01 HL089667NHLBI NIH HHS R01 HL106812NHLBI NIH HHS T32 HL069765NIAID NIH HHS R01 AI042284NIAID NIH HHS R01 AI049460NIAID NIH HHS R01 AI061721NIAID NIH HHS R01 AI064639NIAID NIH HHS R01 AI068149NIAID NIH HHS R01 AI070305NIAID NIH HHS R01 AI074754NIAID NIH HHS R21 AI042284NIAID NIH HHS R37 AI064639NIAID NIH HHS T32 AI007611NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Semi-invariant natural killer T (NKT) cells are innate-like lymphocytes with immunoregulatory properties. NKT cell survival during development requires signal processing by activated RelA/NF-κB. Nonetheless, the upstream signal(s) integrated by NF-κB in developing NKT cells remains incompletely defined. We show that the introgression of Bcl-x

Indexed as

AnimalsApoptosisbcl-X ProteinCell Differentiationfas ReceptorHumansLymphocyte ActivationLymphocytesMiceMice, TransgenicNatural Killer T-CellsNF-kappa BProtein Kinase C-thetaReceptors, Antigen, T-CellReceptors, Tumor Necrosis Factor, Type ISignal TransductionBCL2L1 protein, humanbcl-X Proteinfas ReceptorNF-kappa BProtein Kinase C-thetaReceptors, Antigen, T-CellReceptors, Tumor Necrosis Factor, Type IRELA protein, humanTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID29142275
PMCPMC5688132
OpenAlexW2767463549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.