Evidence map›Paper›PMID 29142240›Full record

ArticleScientific reports2017

Robust Segmentation of the Full Cerebral Vasculature in 4D CT of Suspected Stroke Patients.

Midas Meijs, Ajay Patel, Sil C van de Leemput, Mathias Prokop, Ewoud J van Dijk, Frank-Erik de Leeuw, Frederick J A Meijer, Bram van Ginneken, Rashindra Manniesing

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Midas MeijsDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands. midas.meijs@radboudumc.nl.
Ajay PatelDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Sil C van de LeemputDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Mathias ProkopDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Ewoud J van DijkDepartment of Neurology, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Frank-Erik de LeeuwDepartment of Neurology, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Frederick J A MeijerDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.ORCID 0000-0001-5921-639X
Bram van GinnekenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.
Rashindra ManniesingDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, 6525GA, Nijmegen, The Netherlands.ORCID 0000-0002-4616-6298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance image and parameters, including entropy, of an intensity histogram in a local region at different scales. These histogram parameters revealed to be a strong feature in the detection of vessels regardless of shape and size. The method was trained and tested on a large database of 264 patients with suspicion of acute ischemia who underwent 4D CT in our hospital in the period January 2014 to December 2015. Five subvolumes representing different regions of the cerebral vasculature were annotated in each image in the training set by medical assistants. The evaluation was done on 242 patients. A total of 16 (<8%) patients showed severe under or over segmentation and were reported as failures. One out of five subvolumes was randomly annotated in 159 patients and was used for quantitative evaluation. Quantitative evaluation showed a Dice coefficient of 0.91 ± 0.07 and a modified Hausdorff distance of 0.23 ± 0.22 mm. Therefore, robust vessel segmentation in 4D CT is feasible with good accuracy.

Indexed as

AlgorithmsBlood VesselsFour-Dimensional Computed TomographyHumansImage Processing, Computer-AssistedIschemiaPattern Recognition, AutomatedStroke

Identifiers

PMID29142240
PMCPMC5688074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.