ArticleScientific reports2017
Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 67 citations in OpenAlex.
- Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways.Scientific reports · 2026Article
- Dietary biochar enhances growth performance and feed efficiency in growing pigs evidence from integrated transcriptomic and proteomic analyses.Frontiers in veterinary science · 2026Article
- Plasma apolipoprotein A-I is a causal protective factor in sepsis.Scientific reports · 2025Article
- The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis.Scientific reports · 2025Article
- Association of triglyceride glucose index with sepsis risk after major abdominal surgery: A retrospective cohort study.Pakistan journal of medical sciences · 2025Article
- Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections.Scientific reports · 2025Article
- Association of 28-day mortality with non-high-density lipoprotein cholesterol and the high-density lipoprotein cholesterol ratio (NHHR) in patients with sepsis: Results of MIMIC-IV database analysis.Lipids in health and disease · 2024Article
- Article
- Low HDL-c levels at admission are associated with greater severity and worse clinical outcomes in patients with COVID-19 disease.Atherosclerosis plus · 2023Article
- Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis.Critical care explorations · 2023Review
- Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Proteomic changes associated with racial background and sepsis survival outcomes.Molecular omics · 2022Article
- Advancements in automation for plasma proteomics sample preparation.Molecular omics · 2022Review
- Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients.Angiology · 2022Article
- Article
- Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response.Metabolites · 2022Review
- First Recombinant High-Density Lipoprotein Particles Administration in a Severe ICU COVID-19 Patient, a Multi-Omics Exploratory Investigation.Biomedicines · 2022Article
- The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Puncture Is Attenuated by Menthol: Role of Proliferating Cell Nuclear Antigen and Apoptotic Markers.Frontiers in medicine · 2022Article
- Relationship between liver dysfunction, lipoprotein concentration and mortality during sepsis.PloS one · 2022Observational
- Predictive nomogram model for major adverse kidney events within 30 days in sepsis patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors as age, source of infection and etiology. Recently, genomic and proteomic approaches have improved our understanding of its complex pathogenesis. In the present study, we use quantitative proteomics to evaluate the host proteome response in septic patients secondary to community-acquired pneumonia (CAP). Samples obtained at admission and after 7 days of follow-up were analyzed according to the outcomes of septic patients. The patients' proteome profiles were compared with age- and gender-matched healthy volunteers. Bioinformatic analyses of differentially expressed proteins showed alteration in the cytoskeleton, cellular assembly, movement, lipid metabolism and immune responses in septic patients. Actin and gelsolin changes were assessed in mononuclear cells using immunofluorescence, and a higher expression of gelsolin and depletion of actin were observed in survivor patients. Regarding lipid metabolism, changes in cholesterol, HDL and apolipoproteins were confirmed using enzymatic colorimetric methods in plasma. Transcriptomic studies revealed a massive change in gene expression in sepsis. Our proteomic results stressed important changes in cellular structure and metabolism, which are possible targets for future interventions of sepsis.
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