ArticleScientific reports2017
The effects of artocarpin on wound healing: in vitro and in vivo studies.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial.Scientific reports · 2024Trial
- Anti-Inflammatory Effects of Artocarpin-Loaded Chitosan Microparticles on Inflammatory Chondrocytes.Molecules (Basel, Switzerland) · 2026Article
- Artochalcone-A Geranylated Dihydrochalcone from Male Inflorescences ofMolecules (Basel, Switzerland) · 2026Article
- Natural Extracts in Skin Repair and Wound Healing: Phytochemical Mechanisms and Dermopharmaceutical Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Development of Artocarpin-Loaded Chitosan Particles for Controlled Release and Inflammatory Application.Polymers · 2025Article
- Chitosan Nanofibrous Dressing Increased Angiogenesis and Anti-inflammatory Response in an Acute Wound Model in Rats: A Comparative Study.Annals of biomedical engineering · 2025Article
- Comparison of Wound Healing Effects of Different Micro-Patterned Hydrogels on the Skin of Secondary Intention Rat Model.Gels (Basel, Switzerland) · 2025Article
- Two Novel Membranes Based on Collagen and Polyphenols for Enhanced Wound Healing.International journal of molecular sciences · 2024Article
- Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste.Scientific reports · 2023Article
- Wound healing effects of Asparagus lucidus Lindl extract through the phosphorylation of ERK1/2.BMC complementary medicine and therapies · 2023Article
- Combining Polymer and Cyclodextrin Strategy for Drug Release of Sulfadiazine from Electrospun Fibers.Pharmaceutics · 2023Article
- Phytochemistry and pharmacology of natural prenylated flavonoids.Archives of pharmacal research · 2023Review
- Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective.International journal of molecular sciences · 2023Review
- 3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing.AAPS PharmSciTech · 2023Review
- The Wound Healing Potential ofMycobiology · 2023Review
- Antioxidant, Anti-Inflammation and Antiaging Activities ofAntioxidants (Basel, Switzerland) · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Prenylated Flavonoids in Topical Infections and Wound Healing.Molecules (Basel, Switzerland) · 2022Review
- 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin protects the body against harmful substances and microorganisms. When the skin is damaged, wound healing must be finely regulated to restore the normal function of skin tissue. Artocarpin (ARTO), a prenylated flavonoid purified from the plant Artocarpus communis, has been reported to have anti-inflammatory and anti-cancer properties. The aim of the present study was to evaluate the wound healing potential and therapeutic mechanism of ARTO. Immunohistochemical staining of neutrophils and macrophages and mouse cytokine array analysis demonstrated that ARTO accelerates inflammatory progression and subsequently decreases persistent inflammation. ARTO increases collagen production and increases human fibroblast proliferation and migration by activating the P38 and JNK pathways. Moreover, ARTO increases the proliferation and migration of human keratinocytes through the ERK and P38 pathways and augments human endothelial cell proliferation and tube formation through the Akt and P38 pathways. Together, our data suggested that ARTO enhances skin wound healing, possibly by accelerating the inflammatory phase and by increasing myofibroblast differentiation, proliferation and migration of fibroblasts and keratinocytes, collagen synthesis and maturation, re-epithelialization, and angiogenesis. These findings indicate that ARTO has potential as a potent therapeutic agent for the treatment of skin wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.