ArticleScientific reports2017
Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- A systematic review of microgravity on reproductive systems: Implications for space biology and human health.iScience · 2026Review
- The hierarchical stratum response system of organism to microgravity during spaceflight.Military Medical Research · 2026Review
- Oxidative Damage Under Microgravity Conditions: Response Mechanisms, Monitoring Methods and Countermeasures on Somatic and Germ Cells.International journal of molecular sciences · 2025Review
- The Formation of Stable Lung Tumor Spheroids during Random Positioning Involves Increased Estrogen Sensitivity.Biomolecules · 2024Article
- Article
- Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight.Biomolecules · 2023Article
- Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment.Stem cells international · 2021Review
- A Protective Strategy to Counteract the Oxidative Stress Induced by Simulated Microgravity on H9C2 Cardiomyocytes.Oxidative medicine and cellular longevity · 2021Article
- Implications of Altered Endosome and Lysosome Biology in Space Environments.International journal of molecular sciences · 2020Review
- The effects of microgravity and space radiation on cardiovascular health: From low-Earth orbit and beyond.International journal of cardiology. Heart & vasculature · 2020Review
- Microgravity effects on frozen human sperm samples.Journal of assisted reproduction and genetics · 2020Article
- Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts.International journal of molecular sciences · 2020Article
- Space Radiation Biology for "Living in Space".BioMed research international · 2020Review
- miR-483-3p, Mediated by KLF9, Functions as Tumor Suppressor in Testicular SeminomaFrontiers in oncology · 2020Article
- PGC-1Oxidative medicine and cellular longevity · 2020Review
- Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts.Biomolecules · 2019Article
- Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.Apoptosis : an international journal on programmed cell death · 2019Article
- Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions.International journal of molecular sciences · 2019Article
- Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin's lymphoma cells.Scientific reports · 2018Article
- Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of microgravity on functions of the human body are well described, including alterations in the male and female reproductive systems. In the present study, TCam-2 cells, which are considered a good model of mitotically active male germ cells, were used to investigate intracellular signalling and cell metabolism during exposure to simulated microgravity, a condition that affects cell shape and cytoskeletal architecture. After a 24 hour exposure to simulated microgravity, TCam-2 cells showed 1) a decreased proliferation rate and a delay in cell cycle progression, 2) increased anaerobic metabolism accompanied by increased levels of intracellular Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.