ArticleNature communications2017
Transient cardiomyocyte fusion regulates cardiac development in zebrafish.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cardiomyocyte fusion contributes to cardiac hypertrophy in adult hearts.Molecular medicine (Cambridge, Mass.) · 2026Article
- Cell Fusion in Reprogramming and Regeneration.Advances in experimental medicine and biology · 2026Review
- Single-cell dynamics reveal a stress-induced decision between hypertrophy and apoptosis in neonatal rat cardiomyocytes.Journal of molecular and cellular cardiology plus · 2025Article
- Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis.The EMBO journal · 2025Article
- Adopted neoplastic cells and the consequences of their existence.Oncotarget · 2023Article
- Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders.Nature cell biology · 2022Article
- Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies.European journal of translational myology · 2022Article
- Clonal dominance in excitable cell networks.Nature physics · 2021Article
- Inducible cardiomyocyte injury within the atrioventricular conduction system uncovers latent regenerative capacity in mice.The Journal of clinical investigation · 2021Article
- Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration.Science advances · 2021Article
- Development ofCells · 2021Article
- Polyploid cardiomyocytes: implications for heart regeneration.Development (Cambridge, England) · 2021Article
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- Cell fusion is differentially regulated in zebrafish post-embryonic slow and fast muscle.Developmental biology · 2020Article
- Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Identification of a multipotent Twist2-expressing cell population in the adult heart.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.Circulation research · 2018Review
- Genetics of Cardiovascular Disease: Fishing for Causality.Frontiers in cardiovascular medicine · 2018Review
- Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.WIREs mechanisms of diseaseReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells can sacrifice their individuality by fusing, but the prevalence and significance of this process are poorly understood. To approach these questions, here we generate transgenic reporter lines in zebrafish to label and specifically ablate fused cells. In addition to skeletal muscle cells, the reporters label cardiomyocytes starting at an early developmental stage. Genetic mosaics generated by cell transplantation show cardiomyocytes expressing both donor- and host-derived transgenes, confirming the occurrence of fusion in larval hearts. These fusion events are transient and do not generate multinucleated cardiomyocytes. Functionally, cardiomyocyte fusion correlates with their mitotic activity during development as well as during regeneration in adult animals. By analyzing the cell fusion-compromised jam3b mutants, we propose a role for membrane fusion in cardiomyocyte proliferation and cardiac function. Together, our findings uncover the previously unrecognized process of transient cardiomyocyte fusion and identify its potential role in cardiac development and function.
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