Evidence map›Paper›PMID 29142140›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2018

Imaging and CSF analyses effectively distinguish CJD from its mimics.

Peter Rudge, Harpreet Hyare, Alison Green, John Collinge, Simon Mead

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.Annals of clinical and translational neurology · 2020
    Trial
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  17. Creutzfeldt-Jakob disease and other prion diseases.Nature reviews. Disease primers · 2024
    Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Peter RudgeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Harpreet HyareNHS National Prion Clinic, UCL Hospitals NHS Foundation Trust, London, UK.
Alison GreenThe National CJD Research and Surveillance Unit, Western General Hospital, London, UK.
John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Simon MeadMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
University College London Hospitals NHS Foundation Trust · GBMRC Prion Unit · GBUniversity College London · GBWestern General Hospital · GB

Funding

Chief Scientist Office ETM/58Department of HealthMedical Research Council G0400713Medical Research Council MC_U123160651Medical Research Council MC_UU_00024/1Medical Research Council MR/J016071/1
6 · The paper itself

Abstract

objectiveTo review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis.

methodsReview the clinical findings and investigations in 214 patients enrolled into the UK National Prion Monitoring Cohort Study between October 2008 and November 2015 who had postmortem confirmed sCJD and compare these features with 50 patients referred over the same period who had an alternative final diagnosis (CJD mimics).

resultsPatients with an alternative diagnosis and those with sCJD were of similar age, sex and frequency of dementia but CJD mimics had a longer clinical history. Myoclonus, rigidity and hallucinations were more frequent in patients with sCJD but these features were not helpful in classifying individual patients. Alzheimer's disease, dementia with Lewy bodies and genetic neurodegenerative disorders were alternative diagnoses in more than half of the CJD mimic cases, and 10% had an immune-mediated encephalopathy; lymphoma, hepatic encephalopathy and progressive multifocal leukoencephalopathy were seen more than once. Diffusion-weighted MRI was the most useful readily available test to classify cases correctly (92% CJD, 2% CJD mimics). The CSF cell count, 14-3-3 protein detection and S100B were of limited value. A positive CSF RT-QuIC test, introduced during the course of the study, was found in 89% of tested CJD cases and 0% CJD mimics.

conclusionThe combination of diffusion-weighted MRI analysis and CSF RT-QuIC allowed a perfect classification of sCJD versus its mimics in this study.

Indexed as

14-3-3 ProteinsAdultAgedAged, 80 and overBiomarkersCase-Control StudiesCell CountCreutzfeldt-Jakob SyndromeDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedPrion ProteinsS100 Calcium Binding Protein beta Subunit14-3-3 ProteinsBiomarkersPrion ProteinsS100B protein, humanS100 Calcium Binding Protein beta Subunit

Identifiers

PMID29142140
PMCPMC5909756
OpenAlexW2768263234

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.