Evidence map›Paper›PMID 29142136›Full record

Trial reportJournal of virology2018

Size, Composition, and Evolution of HIV DNA Populations during Early Antiretroviral Therapy and Intensification with Maraviroc.

Antoine Chaillon, Sara Gianella, Steven M Lada, Josué Perez-Santiago, Parris Jordan, Caroline Ignacio, Maile Karris, Douglas D Richman, Sanjay R Mehta, Susan J Little and 2 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Korean Red Ginseng increases defectiveJournal of ginseng research · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Nucleic acid testing and molecular characterization of HIV infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  15. Review
  16. CCR5 Inhibitors and HIV-1 Infection.Journal of AIDS and HIV treatment · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Antoine ChaillonUniversity of California San Diego, La Jolla, California, USA achaillon@ucsd.edu.ORCID http://orcid.org/0000-0001-9490-3857
Sara GianellaUniversity of California San Diego, La Jolla, California, USA.
Steven M LadaUniversity of California San Diego, La Jolla, California, USA.
Josué Perez-SantiagoUniversity of California San Diego, La Jolla, California, USA.
Parris JordanUniversity of California San Diego, La Jolla, California, USA.
Caroline IgnacioUniversity of California San Diego, La Jolla, California, USA.
Maile KarrisUniversity of California San Diego, La Jolla, California, USA.
Douglas D RichmanUniversity of California San Diego, La Jolla, California, USA.
Sanjay R MehtaUniversity of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-2028-8158
Susan J LittleUniversity of California San Diego, La Jolla, California, USA.
Joel O WertheimUniversity of California San Diego, La Jolla, California, USA.
Davey M SmithUniversity of California San Diego, La Jolla, California, USA.
University of California San Diego · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Using NK Cells to eliminate the latent HIV reservoirU19AI096113 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOELK, CHRISTOPHER H · 2011 to 2015
$39.5M
Transmission ProbabilityP01AI074621 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2008 to 2012
$23.1M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Revealing Reservoirs during Rebound (R3)P01AI131385 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEGRUTTOLA, VICTOR GERARD · 2017 to 2021
$8.7M
NCATS NIH HHS UL1 TR000100NIAID NIH HHS K01 AI110181NIAID NIH HHS K24 AI100665NIAID NIH HHS P01 AI074621NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI036214NIAID NIH HHS R24 AI106039NIAID NIH HHS T32 AI007384NIAID NIH HHS U01 AI043638NIAID NIH HHS U01 AI068636NIAID NIH HHS U19 AI096113NIAID NIH HHS UM1 AI068636NIDA NIH HHS DP1 DA034978NIMH NIH HHS R01 MH097520NIMH NIH HHS R01 MH100974NIMH NIH HHS R01 MH101012
6 · The paper itself

Abstract

Residual viremia is common during antiretroviral therapy (ART) and could be caused by ongoing low-level virus replication or by release of viral particles from infected cells. ART intensification should impact ongoing viral propagation but not virion release. Eighteen acutely infected men were enrolled in a randomized controlled trial and monitored for a median of 107 weeks. Participants started ART with (

Indexed as

AdultAntiretroviral Therapy, Highly ActiveBayes TheoremCaliforniaCCR5 Receptor AntagonistsCyclohexanesDNA, ViralDouble-Blind MethodFemaleHIV-1HIV InfectionsHumansMaleMaravirocRNA, ViralTriazolesCCR5 Receptor AntagonistsCyclohexanesDNA, ViralMaravirocRNA, ViralTriazolesART intensificationevolutionHIVmaravirocreservoir

Identifiers

PMID29142136
PMCPMC5774877
OpenAlexW2770030260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.