Evidence map›Paper›PMID 29142129›Full record

ArticleJournal of virology2018

Entry of Human Coronavirus NL63 into the Cell.

Aleksandra Milewska, Paulina Nowak, Katarzyna Owczarek, Artur Szczepanski, Miroslaw Zarebski, Agnieszka Hoang, Krzysztof Berniak, Jacek Wojarski, Slawomir Zeglen, Zbigniew Baster and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Host Glycan-Lectin Interplay in SARS-CoV-2 Infection.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. An orally available MNature communications · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  18. Article
  19. Article
  20. Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Aleksandra Milewska *Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Paulina Nowak *Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Katarzyna OwczarekMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Artur SzczepanskiMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Miroslaw ZarebskiDepartment of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Agnieszka HoangDepartment of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Krzysztof BerniakDepartment of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Jacek WojarskiDepartment of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Zabrze, Poland.
Slawomir ZeglenDepartment of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Zabrze, Poland.
Zbigniew BasterInstitute of Physics, Faculty of Physics, Astronomy and Applied Computer Sciences, Jagiellonian University, Krakow, Poland.
Zenon RajfurInstitute of Physics, Faculty of Physics, Astronomy and Applied Computer Sciences, Jagiellonian University, Krakow, Poland.
Krzysztof PyrcMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland k.a.pyrc@uj.edu.pl.ORCID http://orcid.org/0000-0002-3867-7688
Jagiellonian University · PLSilesian Center for Heart Disease · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first steps of human coronavirus NL63 (HCoV-NL63) infection were previously described. The virus binds to target cells by use of heparan sulfate proteoglycans and interacts with the ACE2 protein. Subsequent events, including virus internalization and trafficking, remain to be elucidated. In this study, we mapped the process of HCoV-NL63 entry into the LLC-Mk2 cell line and

Indexed as

EndocytosisVirus InternalizationCell LineClathrinCoronavirus InfectionsCoronavirus NL63, HumanEndosomesHeparan Sulfate ProteoglycansHumansSpike Glycoprotein, CoronavirusViral Envelope ProteinsClathrinHeparan Sulfate ProteoglycansSpike Glycoprotein, CoronavirusViral Envelope ProteinsclathrinCoronaviridaecoronavirusendocytosisentryHCoV-NL63infectioninternalization

Identifiers

PMID29142129
PMCPMC5774871
OpenAlexW2770110160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.