Evidence map›Paper›PMID 29142125›Full record

ArticleJournal of virology2018

Emergence of Double- and Triple-Gene Reassortant G1P[8] Rotaviruses Possessing a DS-1-Like Backbone after Rotavirus Vaccine Introduction in Malawi.

Khuzwayo C Jere, Chrispin Chaguza, Naor Bar-Zeev, Jenna Lowe, Chikondi Peno, Benjamin Kumwenda, Osamu Nakagomi, Jacqueline E Tate, Umesh D Parashar, Robert S Heyderman and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 77 citations in OpenAlex.

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  9. Phylodynamic characteristics of reassortant DS-1-like G3P[8]-strains of rotavirus type A isolated in Nizhny Novgorod (Russia).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Khuzwayo C JereInstitute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom Khuzwayo.Jere@liverpool.ac.uk.ORCID http://orcid.org/0000-0003-3376-8529
Chrispin ChaguzaInstitute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.ORCID http://orcid.org/0000-0002-2108-1757
Naor Bar-ZeevInstitute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Jenna LoweInstitute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Chikondi PenoMalawi-Liverpool-Wellcome Trust Clinical Research Programme/Department of Medical Laboratory Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.
Benjamin KumwendaMalawi-Liverpool-Wellcome Trust Clinical Research Programme/Department of Medical Laboratory Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.
Osamu NakagomiInstitute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Jacqueline E TateEpidemiology Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Umesh D ParasharEpidemiology Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Robert S HeydermanMalawi-Liverpool-Wellcome Trust Clinical Research Programme/Department of Medical Laboratory Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.
Neil FrenchMalawi-Liverpool-Wellcome Trust Clinical Research Programme/Department of Medical Laboratory Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.
Nigel A Cunliffe *Centre for Global Vaccine Research, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Miren Iturriza-Gomara *Centre for Global Vaccine Research, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
University of Liverpool · GBCenters for Disease Control and Prevention · US

Funding

Wellcome TrustWellcome Trust 091909/Z/10/ZWellcome Trust 201945/Z/16/Z
6 · The paper itself

Abstract

To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunization programs. Malawi incorporated a G1P[8] rotavirus vaccine (Rotarix) into its immunization schedule in 2012. Utilizing a surveillance platform of hospitalized rotavirus gastroenteritis cases, we examined the phylodynamics of G1P[8] rotavirus strains that circulated in Malawi before (1998 to 2012) and after (2013 to 2014) vaccine introduction. Analysis of whole genomes obtained through next-generation sequencing revealed that all randomly selected prevaccine G1P[8] strains sequenced (

Indexed as

Genome, ViralAntigens, ViralGastroenteritisGenetic DriftGenetic VariationHigh-Throughput Nucleotide SequencingHumansMalawiPhylogenyReassortant VirusesRNA-Dependent RNA PolymeraseRNA, ViralRotavirusRotavirus InfectionsRotavirus VaccinesVaccines, AttenuatedAntigens, ViralRIX4414 vaccineRNA-Dependent RNA PolymeraseRNA, ViralRotavirus VaccinesVaccines, Attenuatedgenome reassortmentlineage turnoverMalawiphylodynamicsrotaviruswhole-genome sequencing

Identifiers

PMID29142125
PMCPMC5774894
OpenAlexW2769011684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.