Evidence map›Paper›PMID 29142106›Full record

ArticleOpen biology2017

Soluble Aβ aggregates can inhibit prion propagation.

Claire J Sarell, Emma Quarterman, Daniel C-M Yip, Cassandra Terry, Andrew J Nicoll, Jonathan D F Wadsworth, Mark A Farrow, Dominic M Walsh, John Collinge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Claire J SarellMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Emma QuartermanMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Daniel C-M YipMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Cassandra TerryMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Andrew J NicollMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Jonathan D F WadsworthMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.ORCID 0000-0002-4797-2259
Mark A FarrowMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Dominic M WalshMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK dwalsh3@bwh.harvard.edu.ORCID 0000-0002-0718-6261
John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK jc@prion.ucl.ac.uk.
MRC Prion Unit · GBBrigham and Women's Hospital · US

Funding

Exploiting PrP for the diagnosis and treatment of protein aggregation diseasesR21AG047505 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI WALSH, DOMINIC MARTIN · 2015 to 2016
$493k
Medical Research Council MC_U123160655Medical Research Council MC_U123192748Medical Research Council MC_UU_00024/5Medical Research Council MC_UU_00024/7NIA NIH HHS R21 AG047505
6 · The paper itself

Abstract

Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrP

Indexed as

Amyloid beta-PeptidesAnimalsCell LineMiceProtein BindingPrPC ProteinsPrPSc ProteinsAmyloid beta-PeptidesPrPC ProteinsPrPSc ProteinsAlzheimer's diseaseamyloid β-proteinautomated scrapie cell assayCreutzfeldt–Jakob diseaseprion

Identifiers

PMID29142106
PMCPMC5717343
OpenAlexW2768672683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.