ArticleDiabetes2018
A Partial Loss-of-Function Variant in
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Brain glucose uptake is associated with endogenous glucose production in obese patients before and after bariatric surgery and predicts metabolic outcome at follow-up.Diabetes, obesity & metabolism · 2019Trial
- A functional missense variant iniScience · 2026Article
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms.Current Alzheimer research · 2025Review
- Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues.International journal of molecular sciences · 2024Article
- MODY Only Monogenic? A Narrative Review of theInternational journal of molecular sciences · 2024Review
- UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.European journal of endocrinology · 2024Article
- Kinetic Modeling of Brain [Metabolites · 2024Article
- Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes.Epigenetics · 2023Article
- In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes.Current issues in molecular biology · 2023Article
- Prioritization of genes associated with type 2 diabetes mellitus for functional studies.Nature reviews. Endocrinology · 2023Review
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes.Journal of molecular endocrinology · 2023Article
- Insulin signaling and its application.Frontiers in endocrinology · 2023Review
- Obesity risk is associated with brain glucose uptake and insulin resistance.European journal of endocrinology · 2022Article
- Genetics of Type 2 Diabetes: Past, Present, and Future.Nutrients · 2022Review
- Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline-Does Insulin Have Anything to Do with It? A Narrative Review.Journal of clinical medicine · 2021Review
- The Obesity Risk SNP (rs17782313) near the MC4R Gene Is Not Associated with Brain Glucose Uptake during Insulin Clamp-A Study in Finns.Journal of clinical medicine · 2021Article
- Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort.Diabetes care · 2021Article
- Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.Cerebral cortex communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 3 countries.
Aino Latva-RaskuTurku PET Centre, University of Turku, Turku, Finland.
Miikka-Juhani HonkaTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0001-9875-5863
Alena StančákováInternal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-1375-0252
Heikki A KoistinenUniversity of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Johanna KuusistoInternal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Li GuanDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
Alisa K ManningProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Heather StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
Anna L GloynWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.ORCID 0000-0003-1205-1844
Cecilia M LindgrenProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
T2D-GENES Consortium
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Karen L MohlkeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.
Tomi KarjalainenTurku PET Centre, University of Turku, Turku, Finland.
Lauri NummenmaaTurku PET Centre, University of Turku, Turku, Finland.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu.
Pirjo NuutilaTurku PET Centre, University of Turku, Turku, Finland markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu.ORCID 0000-0001-9597-338X
Markku LaaksoInternal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland markku.laakso@uef.fi pirjo.nuutila@utu.fi boehnke@umich.edu.
University of Turku · FIUniversity of Michigan · USUniversity of Eastern Finland · FIBroad Institute · USCentre for Human Genetics · GBNational Institutes of Health · USUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · US
Funding
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MXOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI RASGON, NATALIE L · 1985 to 2008
$32.4MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MMultiethnic Study of Type 2 Diabetes GenesU01DK085526 · NIDDK · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, JABLONSKI, KATHLEEN ANN · 2009 to 2014
$15.7MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MDiscovery of Functional Variants in Type 2 Diabetes Genes in Mexican AmericansU01DK085524 · NIDDK · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BLANGERO, JOHN, DEFRONZO, RALPH A · 2009 to 2019
$5.9MIdentifying T2D Variants by DNA Sequencing in Multiethnic SamplesU01DK085584 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO, BOEHNKE, MICHAEL L · 2009 to 2013
$4.1MIdentifying variants causal for Type 2 Diabetes in Major human populationsU01DK085545 · NIDDK · UNIVERSITY OF OXFORD · PI CHAN, JULIANA CN, EBRAHIM, SHAH BRIAN · 2009 to 2013
$2.8MIdentification and Replication of Type 2 Diabetes Genes in Mexican AmericansU01DK085501 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HANIS, CRAIG L · 2009 to 2013
$2.7MIntramural NIH HHS Z01 HG000024Medical Research Council MR/L020149/1NCRR NIH HHS M01 RR000070NIDDK NIH HHS K01 DK107836NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK085501NIDDK NIH HHS U01 DK085524NIDDK NIH HHS U01 DK085526NIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK085584NIDDK NIH HHS U01 DK105561Wellcome Trust 200837/Z/16/Z
Abstract
Rare fully penetrant mutations in
Indexed as
Genetic Predisposition to DiseaseInsulin ResistanceLoss of Function MutationAbsorption, PhysiologicalAgedAllelesAmino Acid SubstitutionBlood GlucoseDiabetes Mellitus, Type 2Early DiagnosisFinlandFluorodeoxyglucose F18Follow-Up StudiesGenetic Association StudiesGenetic VariationHeterozygoteAKT2 protein, humanBlood GlucoseFluorodeoxyglucose F18Hypoglycemic AgentsInsulinProto-Oncogene Proteins c-akt
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.