Evidence map›Paper›PMID 29141976›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2017

25-Hydroxyvitamin D as a Biomarker of Vitamin D Status and Its Modeling to Inform Strategies for Prevention of Vitamin D Deficiency within the Population.

Kevin D Cashman, Ellen Ghm van den Heuvel, Ruud Jw Schoemaker, Damien P Prévéraud, Helen M Macdonald, Jayashree Arcot

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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  10. Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
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  17. Vitamin D and Sleep Disorders.Advances in experimental medicine and biology · 2026
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Kevin D CashmanCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Ellen Ghm van den HeuvelFrieslandCampina, Amersfoort, Netherlands.
Ruud Jw SchoemakerFrieslandCampina, Amersfoort, Netherlands.
Damien P PrévéraudCenter of Expertise and Research in Nutrition, Adisseo France SAS, Commentry, France.
Helen M MacdonaldSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
Jayashree ArcotFood Science and Technology Group, School of Chemical Engineering, University of New South Wales, Sydney, New South Wales, Australia.
FrieslandCampina (Netherlands) · NLUniversity College Cork · IEUniversity of Aberdeen · GBUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is substantial evidence that the prevalence of vitamin D deficiency is unacceptably high in the population, and this requires action from a public health perspective. Circulating 25-hydroxyvitamin D [25(OH)D] is a robust and reliable marker of vitamin D status and has been used by numerous agencies in the establishment of vitamin D dietary requirements and for population surveillance of vitamin D deficiency or inadequacy. In a wider context, modeling of serum 25(OH)D data and its contributory sources, namely dietary vitamin D supply and UVB availability, can inform our understanding of population vitamin D status. The aim of this review is to provide the current status of knowledge in relation to modeling of such vitamin D-relevant data. We begin by highlighting the importance of the measurement of 25(OH)D and its standardization, both of which have led to new key data on the prevalence of vitamin D deficiency and inadequacy in North America and Europe. We then overview how state-of-the-art modeling can be used to inform our understanding of the potential effect of ergocalciferol and 25(OH)D on vitamin D intake estimates and how meteorological data on UVB availability, when coupled with other key data, can help predict population serum 25(OH)D concentration, even accounting for seasonal fluctuations, and lastly, how these in silico approaches can help inform policymakers on strategic options on addressing low vitamin D status through food-based approaches and supplementation. The potential of exemplar food-based solutions will be highlighted, as will the possibility of synergies between vitamin D and other dairy food-based micronutrients, in relation to vitamin D status and bone health. Lastly, we will briefly consider the interactions between season and vitamin D supplements on vitamin D status and health.

Indexed as

Nutritional StatusPopulation SurveillanceBiomarkersDietary SupplementsEuropeHumansNorth AmericaNutritional RequirementsSeasonsVitamin DVitamin D Deficiency25-hydroxyvitamin DBiomarkersVitamin D25(OH)D assessmentmathematical modelingUVB availabilityvitamin D deficiencyvitamin D food fortification

Identifiers

PMID29141976
PMCPMC5682995
OpenAlexW2771083886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.