Evidence map›Paper›PMID 29141961›Full record

ArticleGenome research2017

Chromatin accessibility dynamics reveal novel functional enhancers in

Aaron C Daugherty, Robin W Yeo, Jason D Buenrostro, William J Greenleaf, Anshul Kundaje, Anne Brunet

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 218 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. CUT homeobox factors modulate chromatin accessibility in neurons.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. ePerturbDB: enhancer's experimental perturbation database.Database : the journal of biological databases and curation · 2026
    Article
  8. Article
  9. Article
  10. The Binding Landscape of an Essential Nuclear Hormone Receptor inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. A scheduler for rhythmic gene expression.Molecular systems biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. A scheduler for rhythmic gene expression.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aaron C DaughertyDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Robin W YeoDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Jason D BuenrostroDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
William J GreenleafDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, California 94305, USA.
Stanford University · US

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Transgenerational epigenetic inheritance of longevityDP1AG044848 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE · 2012 to 2016
$3.9M
NIA NIH HHS DP1 AG044848NIGMS NIH HHS T32 GM007790
6 · The paper itself

Abstract

Chromatin accessibility, a crucial component of genome regulation, has primarily been studied in homogeneous and simple systems, such as isolated cell populations or early-development models. Whether chromatin accessibility can be assessed in complex, dynamic systems in vivo with high sensitivity remains largely unexplored. In this study, we use ATAC-seq to identify chromatin accessibility changes in a whole animal, the model organism

Indexed as

ChromatinEnhancer Elements, GeneticAmino Acid MotifsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatin Assembly and DisassemblyDNA, HelminthEpigenesis, GeneticNuclear ProteinsCaenorhabditis elegans ProteinsChromatinDNA, HelminthEOR-1 protein, C elegansNuclear Proteins

Identifiers

PMID29141961
PMCPMC5741055
OpenAlexW2950599556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.