ArticleScience translational medicine2017
A role for bacterial urease in gut dysbiosis and Crohn's disease.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04376203 (What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development?), which is not on this map. Cited by 126 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 1 pooled it
15.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development?
Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- Faecal Metabolomics in Paediatric Inflammatory Bowel Disease: A Systematic Review.Journal of Crohn's & colitis · 2022Pooled it
- Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.Scientific reports · 2023Trial
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- Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance.Nature communications · 2021Trial
- FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid.Gastroenterology · 2018Trial
- Trial
- Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.Gut microbes · 2026Review
- Extensive genomic diversity in Desulfovibrio reveals species-specific functional traits associated with disease.Nature communications · 2026Article
- Heat-InactivatedNutrients · 2026Article
- Amino Acid Metabolism in Health and Disease.MedComm · 2026Review
- Research advances in the identification of gut keystone bacteria and formulation of suitable dietary intervention strategies for restoring gut homeostasis.NPJ biofilms and microbiomes · 2026Review
- Seasonal Dynamics of the Gut Microbiome and Functional Adaptations in Sika Deer (Animals : an open access journal from MDPI · 2026Article
- Breath ammonia test for chronic kidney disease screening: impact of fasting on diagnostic accuracy.Clinical kidney journal · 2026Article
- Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods.Frontiers in pediatrics · 2026Article
- D-serine metabolism enhancesCurrent research in microbial sciences · 2026Article
- Genome characterization and comparative genomics ofFrontiers in microbiology · 2026Article
- Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Honeysuckle-Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection.Gastroenterology · 2025Article
- Amino acid competition shapes Acinetobacter baumannii gut carriage.Cell host & microbe · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 5 institutions in 1 country.
Josephine NiDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-0933-6873
Ting-Chin David ShenDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric Z ChenCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Aubrey BaileyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-0712-217X
Manuela RoggianiDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexandra Sirota-MadiBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0003-1507-6107
Elliot S FriedmanDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-0050-4965
Lillian ChauDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew LinDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-1209-2980
Ilana NissimDivision of Child Development, Rehabilitation, and Metabolic Disease, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Justin ScottBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0003-4547-9994
Abigail LauderDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0001-7684-5163
Christopher HoffmannDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-1736-8007
Gloriany RivasDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0001-9776-758X
Lindsey AlbenbergDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0002-2592-8708
Robert N BaldassanoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID http://orcid.org/0000-0003-2337-1923
Jonathan BraunCenter for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID http://orcid.org/0000-0003-1646-2974
Ramnik J XavierBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0002-5630-5167
Clary B ClishBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0001-8259-9245
Marc YudkoffDivision of Child Development, Rehabilitation, and Metabolic Disease, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-9628-9608
Hongzhe LiCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-3662-3907
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-0076-023X
Frederic D BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James D LewisDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-3107-3862
Gary D WuDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. gdwu@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1829-8795
University of Pennsylvania · USBroad Institute · USChildren's Hospital of Philadelphia · USUniversity of California, Los Angeles · USHarvard University · US
Funding
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MUsing polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1MUNIVERSITY OF PENNSYLVANIA TRAINING IN GASTROENTEROLOGYT32DK007066 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1986 to 2026
$11.7MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI PUTT, MARY E. · 2016 to 2020
$6.3MRegulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7MDiet, Genetic Factors, and the Gut Microbiome in Crohn's DiseaseUH2DK083981 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BUSHMAN, FREDERIC D, LEWIS, JAMES D · 2009 to 2010
$2.3MTest-Treat strategy to prevent ulcerative colitis relapseK24DK078228 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEWIS, JAMES D · 2007 to 2016
$1.9MDiet, Genetic Factors, and the Gut Microbiome in Crohn's DiseaseUH3DK083981 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BUSHMAN, FREDERIC D, LEWIS, JAMES D · 2011 to 2012
$1.7MHost-microbial interactions in the gut oxygen equilibriumR01GM103591 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WU, GARY D. · 2013 to 2016
$1.3MNIAID NIH HHS P30 AI045008NICHD NIH HHS U54 HD086984NIDDK NIH HHS K23 DK109136NIDDK NIH HHS K24 DK078228NIDDK NIH HHS P01 DK046763NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK050306NIDDK NIH HHS T32 DK007066NIDDK NIH HHS UH2 DK083981NIDDK NIH HHS UH3 DK083981NIGMS NIH HHS R01 GM080279NIGMS NIH HHS R01 GM103591
Abstract
Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota associated with inflammation of the host gut. We used a combination of shotgun metagenomic sequencing and metabolomics to analyze fecal samples from pediatric patients with Crohn's disease and found an association between disease severity, gut dysbiosis, and bacterial production of free amino acids. Nitrogen flux studies using
Indexed as
AnimalsBacterial ProteinsCrohn DiseaseDysbiosisGastrointestinal MicrobiomeHumansMiceUreaseBacterial ProteinsUrease
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT04376203ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.