Evidence map›Paper›PMID 29141870›Full record

ArticleThe Journal of experimental medicine2017

Igβ ubiquitination activates PI3K signals required for endosomal sorting.

Margaret Veselits, Azusa Tanaka, Yaoqing Chen, Keith Hamel, Malay Mandal, Matheswaran Kandasamy, Balaji Manicassamy, Shannon K O'Neill, Patrick Wilson, Roger Sciammas and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Margaret VeselitsSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.
Azusa TanakaSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.
Yaoqing ChenSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.
Keith HamelSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.
Malay MandalSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.ORCID http://orcid.org/0000-0002-0451-3896
Matheswaran KandasamyDepartment of Microbiology, University of Chicago, Chicago, IL.
Balaji ManicassamyDepartment of Microbiology, University of Chicago, Chicago, IL.
Shannon K O'NeillDivision of Infectious Diseases, University of Colorado, Aurora, CO.
Patrick WilsonSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL.
Roger SciammasCenter for Comparative Medicine, University of California, Davis, Davis, CA.
Marcus R ClarkSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL mclark@uchicago.edu.ORCID http://orcid.org/0000-0001-8755-6260
University of Chicago · USUniversity of California, Davis · USUniversity of Colorado Anschutz Medical Campus · US

Funding

In vivo functions of Ig-beta ubiquitinylationR01GM101090 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2013 to 2016
$1.3M
Regulation of cyclin D3 in B lymphocyte developmentR01GM088847 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2010 to 2013
$1.2M
NIGMS NIH HHS R01 GM088847NIGMS NIH HHS R01 GM101090
6 · The paper itself

Abstract

A wealth of in vitro data has demonstrated a central role for receptor ubiquitination in endocytic sorting. However, how receptor ubiquitination functions in vivo is poorly understood. Herein, we report that ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19 phosphorylation and phosphatidylinositol 3-kinase (PI3K) signals. These signals are necessary and sufficient for accumulating phosphatidylinositol (3,4,5)-trisphosphate (PIP

Indexed as

Signal TransductionUbiquitinationAnimalsB-LymphocytesCD79 AntigensEndocytosisEndosomesHistocompatibility Antigens Class IIImmunity, HumoralMaleMice, Inbred C57BLPhosphatidylinositol 3-KinasePhosphatidylinositol PhosphatesReceptors, Antigen, B-CellToll-Like ReceptorsUbiquitinCD79 AntigensHistocompatibility Antigens Class IIPhosphatidylinositol 3-Kinasephosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesReceptors, Antigen, B-CellToll-Like ReceptorsUbiquitin

Identifiers

PMID29141870
PMCPMC5716028
OpenAlexW2769976974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.