Evidence map›Paper›PMID 29141858›Full record

Trial reportCirculation. Heart failure2017

Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial).

Benjamin W Van Tassell, Justin Canada, Salvatore Carbone, Cory Trankle, Leo Buckley, Claudia Oddi Erdle, Nayef A Abouzaki, Dave Dixon, Dinesh Kadariya, Sanah Christopher and 12 more

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 147 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 4 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01936909 phase2 / phase3completednot on this map

Interleukin-1 Blockade in Recently Decompensated Heart Failure: A Randomized Placebo-controlled Double-blinded Study

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2014 to 2016Enrolled60ConditionsHeart FailureArmsAnakinra (weeks 1-2), Anakinra (weeks 3-12), Placebo
NCT06286423 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction: a Pilot Study

TypeinterventionalSponsorUniversity of VirginiaRan2024 to 2028Enrolled30ConditionsHeart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection FractionArmsColchicine 0.6 mg, Control/Placebo group
3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 233 citations in OpenAlex.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Benjamin W Van TassellFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Justin CanadaFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Salvatore CarboneFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Cory TrankleFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Leo BuckleyFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Claudia Oddi ErdleFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Nayef A AbouzakiFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Dave DixonFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Dinesh KadariyaFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Sanah ChristopherFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Aaron SchatzFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Jessica ReganFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Michele ViscusiFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Marco Del BuonoFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Ryan MelchiorFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Pranav MankadFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Juan LuFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Robin SculthorpeFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Giuseppe Biondi-ZoccaiFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Edward LesnefskyFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Ross ArenaFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.).
Antonio AbbateFrom the Department of Pharmacotherapy and Outcomes Science (B.W.V.T., L.F.B., D.L.D.), VCU Pauley Heart Center (B.W.V.T, J.M.C., S.C., C.T., C.O.E., N.A.A., D.L.D., D.K., S.C., A.S., J.R., M.V., M.D.B., R.M., P.M., E.L., A.A.), Department of Family Medicine and Population Health (J.L.), and Investigational Pharmacy (R.S.), Virginia Commonwealth University, Richmond; Department of Experimental Medicine, Sapienza University of Rome, Italy (S.C.); Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy (G.B.-Z.); Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy (G.B.-Z.); Division of Cardiology, Hunter Holmes McGuire Veterans Administration Hospital, Richmond, VA (E.L.); and Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago (R.A.). antonio.abbate@vcuhealth.org.
Istituto Neurologico Mediterraneo · ITSapienza University of Rome · ITHunter Holmes McGuire VA Medical Center · US

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Interleukin-1 blockade in recently decompensated heart failureR34HL117026 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABBATE, ANTONIO, VAN TASSELL, BENJAMIN W · 2013 to 2014
$671k
NCATS NIH HHS UL1 TR000058NHLBI NIH HHS R34 HL117026
6 · The paper itself

Abstract

backgroundAn enhanced inflammatory response predicts worse outcomes in heart failure (HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist (anakinra) could inhibit the inflammatory response and improve peak aerobic exercise capacity in patients with recently decompensated systolic HF. METHODS AND

resultsWe randomly assigned 60 patients with reduced left ventricular ejection fraction (<50%) and elevated C-reactive protein levels (>2 mg/L), within 14 days of hospital discharge, to daily subcutaneous injections with anakinra 100 mg for 2 weeks, 12 weeks, or placebo. Patients underwent measurement of peak oxygen consumption (Vo

conclusionsNo change in peak Vo CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01936909.

Indexed as

AgedAnti-Inflammatory AgentsBiomarkersC-Reactive ProteinDisease-Free SurvivalDrug Administration ScheduleEchocardiography, DopplerExercise TestExercise ToleranceFemaleHeart FailureHumansInflammation MediatorsInterleukin-1Interleukin 1 Receptor Antagonist ProteinMaleAnti-Inflammatory AgentsBiomarkersC-Reactive ProteinInflammation MediatorsInterleukin-1Interleukin 1 Receptor Antagonist Proteinheart failureheart failure, systolicinflammationinterleukin-1myocardial infarction

Identifiers

PMID29141858
PMCPMC5699505
OpenAlexW2770646430

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.