ArticleMultiple sclerosis and related disorders2017
Examining the contributions of environmental quality to pediatric multiple sclerosis.
Article in Multiple sclerosis and related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Geospatial analysis of environmental atmospheric risk factors in neurodegenerative diseases: a systematic review update.Systematic reviews · 2024Pooled it
- Association between ambient air pollution and multiple sclerosis: a systemic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Geospatial Analysis of Environmental Atmospheric Risk Factors in Neurodegenerative Diseases: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Ozone pollution as a possible trigger for multiple sclerosis in young people: the PEDIGREE study.Journal of neurology · 2026Article
- A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Environmental Influences on Risk and Disease Course in Pediatric Multiple Sclerosis.Seminars in pediatric neurology · 2023Article
- Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Air pollution and multiple sclerosis: a comprehensive review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Environmental and genetic risk factors for MS: an integrated review.Annals of clinical and translational neurology · 2019Review
- Urban air quality and associations with pediatric multiple sclerosis.Annals of clinical and translational neurology · 2018Article
- Associations between environmental quality and adult asthma prevalence in medical claims data.Environmental research · 2018Article
- The Aryl Hydrocarbon Receptor as an Immune-Modulator of Atmospheric Particulate Matter-Mediated Autoimmunity.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
29 authors at 16 institutions in 1 country.
Funding
Abstract
backgroundMultiple sclerosis (MS) is a presumed autoimmune disease caused by genetic and environmental factors. It is hypothesized that environmental exposures (such as air and water quality) trigger the innate immune response thereby activating a pro-inflammatory cascade.
objectiveTo examine potential environmental factors in pediatric MS using geographic information systems (GIS).
methodsPediatric MS cases and healthy controls were identified as part of an ongoing multicenter case-control study. Subjects' geographic locations were mapped by county centroid to compare to an Environmental Quality Index (EQI). The EQI examines 5 individual environmental components (air, land, water, social, built factors). A composite EQI score and individual scores were compared between cases and controls, stratified by median proximity to enrollment centers (residence <20 or ≥20 miles from the recruiting center), using logistic regression.
resultsOf the 287 MS cases and 445 controls, 46% and 49% respectively live in areas where the total EQI is the highest (worst environmental quality). Total EQI was not significantly associated with the odds for MS (p = 0.90 < 20 miles from center; p = 0.43 ≥ 20 miles); however, worsening air quality significantly impacted the odds for MS in those living near a referral center (OR = 2.83; 95%CI 1.5, 5.4) and those who reside ≥ 20 miles from a referral center (OR = 1.61; 95%CI 1.2, 2.3).
conclusionAmong environmental factors, air quality may contribute to the odds of developing MS in a pediatric population. Future studies will examine specific air constituents and other location-based air exposures and explore potential mechanisms for immune activation by these exposures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.