Evidence map›Paper›PMID 29141755›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Case Report: Failure of Therapeutic Coma in Rabies Encephalitis.

Abi Manesh, Reeta Subramaniam Mani, Kishore Pichamuthu, Manjeera Jagannati, Vivek Mathew, Rajiv Karthik, Ooriapadickal Cherian Abraham, Geeta Chacko, George M Varghese

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Recent updates on laboratory diagnosis of rabies.The Indian journal of medical research · 2024
    Review
  2. Case Report: Survival from Clinical Rabies in a Young Child from Maharashtra, India, 2022.The American journal of tropical medicine and hygiene · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Abi ManeshDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Reeta Subramaniam ManiDepartment of Neurovirology, WHO Collaborating Centre for Reference and Research on Rabies, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Kishore PichamuthuDivision of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India.
Manjeera JagannatiDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Vivek MathewDepartment of Neurological Sciences, Neurology Unit, Christian Medical College, Vellore, Tamil Nadu, India.
Rajiv KarthikDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Ooriapadickal Cherian AbrahamDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Geeta ChackoSection of Neuropathology, Department of Neurological Sciences & Pathology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
George M VargheseDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Christian Medical College & Hospital · INChristian Medical College · INNational Institute of Mental Health and Neurosciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rabies encephalitis is a fulminant, almost universally fatal infection involving the central nervous system. A unique treatment protocol, including anti-exicitotoxic therapy and induced coma was credited with the survival of a vaccinated teenager with bat rabies encephalitis in 2005. However, multiple efforts to replicate this expensive and intense protocol have not been successful. In this article, we report the failure of the protocol in Indian patients with canine-acquired rabies and elucidate the potential explanations for the failure of the protocol in our patients.

Indexed as

AdolescentAdultComaEncephalitis, ViralFatal OutcomeHumansMaleRabiesTreatment Failure

Identifiers

PMID29141755
PMCPMC5928693
OpenAlexW2765720663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.