ArticleThe American journal of tropical medicine and hygiene2017
Spatio-Temporal Dynamics of Asymptomatic Malaria: Bridging the Gap Between Annual Malaria Resurgences in a Sahelian Environment.
Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Pooled it
- High Burden of Asymptomatic Malaria Among Schoolchildren in Nigeria: Diagnosis Challenges andPathogens (Basel, Switzerland) · 2026Article
- Analysis of clinical malaria hotspots according to transmission levels in two health areas of the Kolondieba health district, Mali.MalariaWorld journal · 2026Article
- Hidden burden of malaria in pregnancy in hard-to-reach areas of Odisha, India: challenges to elimination and the case for integrating molecular surveillance.Frontiers in public health · 2026Article
- Sociodemographic and socioeconomic predictors of asymptomatic malaria among children and adolescents in rural Guinea: a longitudinal study.Frontiers in public health · 2026Article
- Prospective acceptability of mass drug administration for malaria in Kedougou region in Senegal: a mixed method study.Malaria journal · 2024Article
- Modeling the Impact of Proactive Community Case Management on Reducing Confirmed Malaria Cases in Sub-Saharan African Countries.The American journal of tropical medicine and hygiene · 2024Article
- Modeling clinical malaria episodes in different ecological settings in Mali, 2018-2022.IJID regions · 2024Article
- Spatio-Temporal Variability of Malaria Incidence in the Health District of Kati, Mali, 2015-2019.International journal of environmental research and public health · 2022Article
- Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests.Tropical medicine and infectious disease · 2022Review
- Sub-national tailoring of seasonal malaria chemoprevention in Mali based on malaria surveillance and rainfall data.Parasites & vectors · 2022Article
- Stratification at the health district level for targeting malaria control interventions in Mali.Scientific reports · 2022Article
- Trends in malaria epidemiological factors following the implementation of current control strategies in Dangassa, Mali.Malaria journal · 2022Article
- Host and Parasite Transcriptomic Changes upon Successive Plasmodium falciparum Infections in Early Childhood.mSystems · 2020Article
- Spatio-Temporal Dynamic of Malaria Incidence: A Comparison of Two Ecological Zones in Mali.International journal of environmental research and public health · 2020Article
- Spatio-temporal variation of malaria hotspots in Central Senegal, 2008-2012.BMC infectious diseases · 2020Article
- Application of Functional Data Analysis to Identify Patterns of Malaria Incidence, to Guide Targeted Control Strategies.International journal of environmental research and public health · 2020Article
- Geo-Epidemiology of Malaria at the Health Area Level, Dire Health District, Mali, 2013-2017.International journal of environmental research and public health · 2020Article
- Article
- Socioeconomic and environmental factors associated with malaria hotspots in the Nanoro demographic surveillance area, Burkina Faso.BMC public health · 2019Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In areas of seasonal malaria transmission, the incidence rate of malaria infection is presumed to be near zero at the end of the dry season. Asymptomatic individuals may constitute a major parasite reservoir during this time. We conducted a longitudinal analysis of the spatio-temporal distribution of clinical malaria and asymptomatic parasitemia over time in a Malian town to highlight these malaria transmission dynamics. For a cohort of 300 rural children followed over 2009-2014, periodicity and phase shift between malaria and rainfall were determined by spectral analysis. Spatial risk clusters of clinical episodes or carriage were identified. A nested-case-control study was conducted to assess the parasite carriage factors. Malaria infection persisted over the entire year with seasonal peaks. High transmission periods began 2-3 months after the rains began. A cluster with a low risk of clinical malaria in the town center persisted in high and low transmission periods. Throughout 2009-2014, cluster locations did not vary from year to year. Asymptomatic and gametocyte carriage were persistent, even during low transmission periods. For high transmission periods, the ratio of asymptomatic to clinical cases was approximately 0.5, but was five times higher during low transmission periods. Clinical episodes at previous high transmission periods were a protective factor for asymptomatic carriage, but carrying parasites without symptoms at a previous high transmission period was a risk factor for asymptomatic carriage. Stable malaria transmission was associated with sustained asymptomatic carriage during dry seasons. Control strategies should target persistent low-level parasitemia clusters to interrupt transmission.
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