Evidence map›Paper›PMID 29141713›Full record

Trial reportThe American journal of tropical medicine and hygiene2017

Resource Use and Costs of Dengue: Analysis of Data from Phase III Efficacy Studies of a Tetravalent Dengue Vaccine.

Hanna El Fezzazi, Marie Branchu, Gabriel Carrasquilla, Punnee Pitisuttithum, Ana Paula Perroud, Carina Frago, Laurent Coudeville

2 registry-linked trialsAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01373281 phase3completednot on this map

Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia

TypeinterventionalSponsorSanofi Pasteur, a Sanofi CompanyRan2011 to 2017Enrolled10,275ConditionsDengue, Dengue Fever, Dengue Hemorrhagic FeverArmsLive, attenuated, dengue serotype 1, 2, 3, 4 virus, Placebo: Sodium chloride (NaCl) 0.9%
NCT01374516 phase3completednot on this map

Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America

TypeinterventionalSponsorSanofi Pasteur, a Sanofi CompanyRan2011 to 2018Enrolled20,869ConditionsDengue Fever, Dengue Hemorrhagic Fever, DengueArmsLive, attenuated, dengue serotype 1, 2, 3, 4 virus, Placebo: (NaCl) 0.9% solution
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Cost of dengue in Colombia: A systematic review.PLoS neglected tropical diseases · 2024
    Pooled it
  2. Pooled it
  3. Efficacy of Tetravalent Dengue Vaccine: A Systematic Review and Meta-Analysis.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hanna El FezzaziDengue Vaccination Impact and Economics, Sanofi Pasteur, Lyon, France.
Marie BranchuEcole des Hautes Etudes en Santé Publique (EHESP)-ESSEC Business School, Cergy, France.
Gabriel CarrasquillaFundación Santa Fe de Bogotá, Bogotá, Colombia.
Punnee PitisuttithumVaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Ana Paula PerroudClinical Research and Development, Sanofi Pasteur, Sâo Paulo, Brazil.
Carina FragoClinical Sciences, Sanofi Pasteur, Singapore, Singapore.
Laurent CoudevilleDengue Vaccination Impact and Economics, Sanofi Pasteur, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A tetravalent dengue vaccine (CYD-TDV) has recently been approved in 12 countries in southeast Asia and Latin America for individuals aged 9-45 years or 9-60 years (age indication approvals vary by country) living in endemic areas. Data on utilization of medical and nonmedical resources as well as time lost from school and work were collected during the active phase of two phase III efficacy studies performed in 10 countries in the Asia-Pacific region and Latin America (NCT01373281; NCT01374516). We compared dengue-related resource utilization and costs among vaccinated and nonvaccinated participants. Country-specific unit costs were derived from available literature. There were 901 virologically confirmed dengue episodes among participants aged ≥ 9 years (

Indexed as

Costs and Cost AnalysisAdolescentAntibodies, ViralAsiaChildChild, PreschoolDengueDengue VaccinesDengue VirusFemaleHospitalizationHumansLatin AmericaMaleVaccinationAntibodies, ViralDengue Vaccines

Identifiers

PMID29141713
PMCPMC5805027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.