ArticleGenome biology2017
Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives.
Article in Genome biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 83 citations in OpenAlex.
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.The New phytologist · 2025Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- Evolutionary Systems Biology Identifies Genetic Trade-offs in Rice Defense against Aboveground and Belowground Attackers.Plant & cell physiology · 2025Article
- Trans-Specific Polymorphisms Between Cryptic Daphnia Species Affect Fitness and Behavior.Molecular ecology · 2025Article
- Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium).Plant biotechnology journal · 2024Article
- Balancing selection and the functional effects of shared polymorphism in crypticbioRxiv : the preprint server for biology · 2024Article
- Adaptive Selection of Cis-regulatory Elements in the Han Chinese.Molecular biology and evolution · 2024Article
- Balancing selection on an MYB transcription factor maintains the twig trichome color variation in Melastoma normale.BMC biology · 2023Article
- Molecular mechanisms of adaptive evolution in wild animals and plants.Science China. Life sciences · 2023Review
- Transposable elements maintain genome-wide heterozygosity in inbred populations.Nature communications · 2022Article
- Predicting Cloned Disease Resistance Gene Homologs (CDRHs) in Radish, Underutilised Oilseeds, and Wild Brassicaceae Species.Plants (Basel, Switzerland) · 2022Article
- Challenges and Perspectives in the Study of Self-Incompatibility in Orchids.International journal of molecular sciences · 2021Review
- An atlas of CNV maps in cattle, goat and sheep.Science China. Life sciences · 2021Article
- Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans.Nature ecology & evolution · 2021Article
- Genome-wide DNA mutations in Arabidopsis plants after multigenerational exposure to high temperatures.Genome biology · 2021Article
- Article
- Arabidopsis natural variation in insect egg-induced cell death reveals a role for LECTIN RECEPTOR KINASE-I.1.Plant physiology · 2021Article
- Ecological Load and Balancing Selection in Circumboreal Barnacles.Molecular biology and evolution · 2021Article
- Global allele polymorphism indicates a high rate of allele genesis at a locus under balancing selection.Heredity · 2021Article
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIn contrast to positive selection, which reduces genetic variation by fixing beneficial alleles, balancing selection maintains genetic variation within a population or species and plays crucial roles in adaptation in diverse organisms. However, which genes, genome-wide, are under balancing selection and the extent to which these genes are involved in adaptation are largely unknown.
resultsWe performed a genome-wide scan for genes under balancing selection across two plant species, Arabidopsis thaliana and its relative Capsella rubella, which diverged about 8 million generations ago. Among hundreds of genes with shared coding-region polymorphisms, we find evidence for long-term balancing selection in five genes: AT1G35220, AT2G16570, AT4G29360, AT5G38460, and AT5G44000. These genes are involved in the response to biotic and abiotic stress and other fundamental biochemical processes. More intriguingly, for these genes, we detected significant ecological diversification between the two haplotype groups, suggesting that balancing selection has been very important for adaptation.
conclusionsOur results indicate that beyond the well-known S-locus genes and resistance genes, many loci are under balancing selection. These genes are mostly correlated with resistance to stress or other fundamental functions and likely play a more important role in adaptation to diverse habitats than previously thought.
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