Evidence map›Paper›PMID 29141651›Full record

SynthesisThe international journal of behavioral nutrition and physical activity2017

The dose of behavioral interventions to prevent and treat childhood obesity: a systematic review and meta-regression.

William J Heerman, Meghan M JaKa, Jerica M Berge, Erika S Trapl, Evan C Sommer, Lauren R Samuels, Natalie Jackson, Jacob L Haapala, Alicia S Kunin-Batson, Barbara A Olson-Bullis and 3 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The international journal of behavioral nutrition and physical activity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01316653 (Growing Right Onto Wellness), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01316653 nacompletednot on this map

Growing Right Onto Wellness (GROW): Changing Early Childhood Body Mass Index (BMI) Trajectories

TypeinterventionalSponsorVanderbilt UniversityRan2011 to 2017Enrolled610ConditionsOverweight and Obesity, Childhood ObesityArmsGROW Healthier, GROW Smarter
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Early-life adversity before age 5 is associated with reduced cardiometabolic health characterized by increased arterial stiffness and inflammation in adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  13. Review
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  20. Preventing Childhood Obesity in Primary Schools: A Realist Review from UK Perspective.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

William J HeermanDepartment of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Ave, 2nd Floor, Nashville, TN, 37212, USA. Bill.Heerman@vanderbilt.edu.
Meghan M JaKaDivision of Applied Research, Allina Health, Minneapolis, USA.
Jerica M BergeDepartment of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, USA.
Erika S TraplDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, USA.
Evan C SommerDepartment of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Ave, 2nd Floor, Nashville, TN, 37212, USA.
Lauren R SamuelsDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA.
Natalie JacksonDepartment of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Ave, 2nd Floor, Nashville, TN, 37212, USA.
Jacob L HaapalaDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA.
Alicia S Kunin-BatsonHealthPartners Institute, Minneapolis, USA.
Barbara A Olson-BullisHealthPartners Institute, Minneapolis, USA.
Heather K HardinFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, USA.
Nancy E SherwoodHealthPartners Institute, Minneapolis, USA.
Shari L BarkinDepartment of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Ave, 2nd Floor, Nashville, TN, 37212, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Clinic, Family & Community Collaboration to Treat Overweight and Obese ChildrenU01HL103629 · NHLBI · STANFORD UNIVERSITY · PI ROBINSON, THOMAS N. · 2010 to 2016
$12.6M
TARGETING OBESITY AND BLOOD PRESSURE IN URBAN YOUTHU01HL103622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BORAWSKI, ELAINE A., MOORE, SHIRLEY M · 2010 to 2016
$12.2M
Growing Right Onto Wellness (GROW): Changing Early Childhood BMI TrajectoriesU01HL103620 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARKIN, SHARI · 2010 to 2016
$11.9M
Linking Primary Care, Communities and Families to Prevent Obesity Among PreschoolU01HD068890 · NICHD · UNIVERSITY OF MINNESOTA · PI FRENCH, SIMONE A., SHERWOOD, NANCY E. · 2010 to 2016
$11.0M
Gene Modifiers in CF Lung DiseaseR01HL068890 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNOWLES, MICHAEL R · 2001 to 2014
$9.5M
Childhood Obesity Prevention and Treatment Research Coordinating UnitU01HL103561 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEVENS, JUNE · 2010 to 2017
$7.0M
Vanderbilt Center for Diabetes Translation ResearchP30DK092986 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OSBORN, CHANDRA Y. · 2011 to 2020
$6.7M
Multiple Chronic Conditions_Interdisciplinary Nurse Scientist TrainingT32NR015433 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MOORE, SHIRLEY M · 2015 to 2019
$1.9M
GROW Baby: Improving Maternal Gestational Weight Gain and Infant Growth in the Growing Right Onto Wellness (GROW) TrialK23HL127104 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEERMAN, WILLIAM · 2016 to 2020
$914k
National Heart, Lung, and Blood Institute (US) K23HL127104National Heart, Lung, and Blood Institute (US) U01HL103620National Institute of Nursing Research (US) T32 NR015433-01NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NHLBI NIH HHS K23 HL127104NHLBI NIH HHS U01HD068890NHLBI NIH HHS U01 HL103561NHLBI NIH HHS U01HL103561NHLBI NIH HHS U01 HL103620NHLBI NIH HHS U01 HL103622NHLBI NIH HHS U01HL103622NHLBI NIH HHS U01 HL103629NHLBI NIH HHS U01HL103629NICHD NIH HHS U01 HD068890NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK092986NIDDK NIH HHS P30DK092986NINR NIH HHS T32 NR015433
6 · The paper itself

Abstract

backgroundA better understanding of the optimal "dose" of behavioral interventions to affect change in weight-related outcomes is a critical topic for childhood obesity intervention research. The objective of this review was to quantify the relationship between dose and outcome in behavioral trials targeting childhood obesity to guide future intervention development.

methodsA systematic review and meta-regression included randomized controlled trials published between 1990 and June 2017 that tested a behavioral intervention for obesity among children 2-18 years old. Searches were conducted among PubMed (Web-based), Cumulative Index to Nursing and Allied Health Literature (EBSCO platform), PsycINFO (Ovid platform) and EMBASE (Ovid Platform). Two coders independently reviewed and abstracted each included study. Dose was extracted as intended intervention duration, number of sessions, and length of sessions. Standardized effect sizes were calculated from change in weight-related outcome (e.g., BMI-Z score).

resultsOf the 258 studies identified, 133 had sufficient data to be included in the meta-regression. Average intended total contact (# sessions x length of sessions) was 27.7 (SD 32.2) hours and average duration was 26.0 (SD 23.4) weeks. When controlling for study covariates, a random-effects meta-regression revealed no significant association between contact hours, intended duration or their interaction and effect size.

conclusionsThis systematic review identified wide variation in the dose of behavioral interventions to prevent and treat pediatric obesity, but was unable to detect a clear relationship between dose and weight-related outcomes. There is insufficient evidence to provide quantitative guidance for future intervention development. One limitation of this review was the ability to uniformly quantify dose due to a wide range of reporting strategies. Future trials should report dose intended, delivered, and received to facilitate quantitative evaluation of optimal dose. TRIAL REGISTRATIONS: The protocol was registered on PROSPERO (Registration # CRD42016036124 ).

Indexed as

Health BehaviorAdolescentChildChild, PreschoolDietExerciseHumansPediatric ObesityRandomized Controlled Trials as TopicBehavioral interventionChildhood obesityDoseHealth behaviorSystematic review

Identifiers

PMID29141651
PMCPMC5688650

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.