Evidence map›Paper›PMID 29141593›Full record

ArticleBMC cancer2017

Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.

Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim, Sung-Gil Chi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 24 citations in OpenAlex.

  1. Caveolin and NOS in the Development of Muscular Dystrophy.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Byung-Kyu RyuSchool of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
Min-Goo LeeSchool of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
Nam-Hoon KimDepartment of Internal Medicine, College of Medicine, Inje University, Goyang, South Korea.
Kil Yeon LeeDepartment of General Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea.
Shin-Ju OhDepartment of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea.
Jung-Rock MoonDepartment of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea.
Hyo Jong KimDepartment of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea.
Sung-Gil ChiSchool of Life Sciences and Biotechnology, Korea University, Seoul, South Korea. chi6302@korea.ac.kr.
Kyung Hee University · KRKorea University · KRInje University · KR

Funding

Korea University Intramural Grant-in-Aid 2016National Research Foundation of Korea NRF-2015R1A2A1A01005389
6 · The paper itself

Abstract

backgroundExpression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression.

methodsTo explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized.

resultsA substantial fraction of primary tumors and cell lines displayed abnormally low or high Cav-1 mRNA expression, indicating the bidirectional alteration of Cav-1 in gastric cancers. While allelic imbalance and mutational alterations of the Cav-1 gene were rarely detected, aberrant promoter hyper- or hypo-methylation showed a tight correlation with bidirectional alteration of its expression. Abnormally low and high Cav-1 expression was more frequently observed in early and advanced cancers, respectively, suggesting the oncogenic switch of its function in tumor progression. Cell cycle progression, DNA synthesis, and colony forming ability were markedly decreased by Cav-1 transfection in low-expressing tumor cells but by its depletion in high-expressing cells. Interestingly, Cav-1 exerted opposite effects on MEK-ERK signaling in these two cell types through the reciprocal regulation of the RAF-ERK negative feedback loop. A feedback inhibition of RAF by ERK was stimulated by restoration of Cav-1 expression in low-expressing cells but by it depletion in high-expressing cells. As predicted, the opposite effects of Cav-1 on both tumor cell growth and inhibitory RAF phosphorylation were abolished if ERK is depleted.

conclusionBidirectional alteration of Cav-1 is linked to its opposite effects on gastric tumor cell growth, which stem from the reciprocal control on the RAF-ERK negative feedback loop.

Indexed as

Gene Expression Regulation, NeoplasticCaveolin 1Disease ProgressionDNA MethylationExtracellular Signal-Regulated MAP KinasesHumansModels, BiologicalMutationPolymorphism, GeneticPromoter Regions, Geneticraf KinasesStomach NeoplasmsCAV1 protein, humanCaveolin 1Extracellular Signal-Regulated MAP Kinasesraf KinasesCaveolinErkGastric cancerPromoter methylationRAF

Identifiers

PMID29141593
PMCPMC5688627
OpenAlexW2768273324

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.