ArticleJournal of intensive care medicine2020
Development of a Simple Sequential Organ Failure Assessment Score for Risk Assessment of Emergency Department Patients With Sepsis.
Article in Journal of intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A comparison of qSOFA, SIRS and NEWS in predicting the accuracy of mortality in patients with suspected sepsis: A meta-analysis.PloS one · 2022Pooled it
- Quick Sequential Organ Failure Assessment as a prognostic factor for infected patients outside the intensive care unit: a systematic review and meta-analysis.Internal and emergency medicine · 2019Pooled it
- Article
- Mortality prediction by quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index in suspected sepsis: A retrospective study.The Journal of international medical research · 2026Observational
- Performance of a modified Sequential Organ Failure Assessment score in pre-hospital critical care to predict short-term mortality: a prospective, multicentre, validation cohort study.EClinicalMedicine · 2025Article
- Racial disparities in septic shock mortality: a retrospective cohort study.Lancet regional health. Americas · 2024Article
- Application Prospect of the SOFA Score and Related Modification Research Progress in Sepsis.Journal of clinical medicine · 2023Review
- Article
- The Use of Different Sepsis Risk Stratification Tools on the Wards and in Emergency Departments Uncovers Different Mortality Risks: Results of the Three Welsh National Multicenter Point-Prevalence Studies.Critical care explorations · 2021Article
- Most emergency department patients meeting sepsis criteria are not diagnosed with sepsis at discharge.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis.Journal of intensive care medicine · 2020Article
- Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Prevalence of organ failure and mortality among patients in the emergency department: a population-based cohort study.BMJ open · 2019Observational
- Accuracy of qSOFA for the diagnosis of sepsis-3: a secondary analysis of a population-based cohort study.Journal of thoracic disease · 2019Article
- qSOFA is a Poor Predictor of Short-Term Mortality in All Patients: A Systematic Review of 410,000 Patients.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesSepsis-3 recommends using the quick Sequential Organ Failure Assessment (qSOFA) score followed by SOFA score for sepsis evaluation. The SOFA is complex and unfamiliar to most emergency physicians, while qSOFA is insensitive for sepsis screening and may result in missed cases of sepsis. The objective of this study was to devise an easy-to-use simple SOFA score for use in the emergency department (ED).
methodsRetrospective study of ED patients with sepsis with in-hospital mortality as the primary outcome. A simple SOFA score was derived and validated and compared with SOFA and qSOFA.
resultsA total of 3297 patients with sepsis were included, and in-hospital mortality was 10.1%. Simple SOFA had a sensitivity and specificity of 88% and 44% in the derivation set and 93% and 44% in the validation set for in-hospital mortality, respectively. The sensitivity and specificity of qSOFA was 38% and 86% and for SOFA was 90% and 50%, respectively. There were 2760 (84%) of 3297 qSOFA-negative (<2) patients. In this group, simple SOFA had a sensitivity and specificity of 86% and 48% in the derivation set and 91% and 48% in the validation set, respectively. Sequential Organ Failure Assessment was 86% sensitive and 57% specific in qSOFA-negative patients. For all encounters, the areas under the receiver-operator characteristic curves (AUROC) were 0.82 for SOFA, 0.78 (derivation) and 0.82 (validation) for simple SOFA, and 0.68 for qSOFA. In qSOFA-negative patients, the AUROCs were 0.80 for SOFA and 0.76 (derivation) and 0.82 (validation) for simple SOFA.
conclusionsSimple SOFA demonstrates similar predictive ability for in-hospital mortality from sepsis compared to SOFA. External validation of these findings is indicated.
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