Evidence map›Paper›PMID 29141483›Full record

ArticleRenal failure2017

Red blood cell distribution width as a marker of cerebral infarction in hemodialysis patients.

Liyi Mo, Yuanhan Chen, Zhilian Li, Lixia Xu, Wei Dong, Li Zhang, Huaban Liang, Ruizhao Li, Yiming Tao, Wei Shi and 1 more

Abstract read
In one paragraph

Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Platelet indices and stroke.Renal failure · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Liyi Moa Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Yuanhan Chena Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Zhilian Lia Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Lixia Xua Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Wei Donga Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Li Zhanga Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Huaban Lianga Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Ruizhao Lia Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Yiming Taoa Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Wei Shia Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.
Xinling Lianga Department of Nephrology , Guangdong General Hospital and Guangdong Academy of Medical Sciences , Guangzhou , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRed blood cell distribution width (RDW) is a cardiovascular biomarker. We evaluated the association between RDW and cerebral stroke risk in hemodialysis patients.

methodsA cohort of 442 adult patients on hemodialysis was studied. Strokes were defined according to ICD-10 diagnosis codes. Routine complete blood counts, evaluated every 3-6 months, were used for RDW values.

resultsAmong 442 hemodialysis patients, during the 50-month follow-up, there were 62 cases (14.0%) of cerebral stroke: 41 (9.3%) with cerebral infarction and 21 (4.8%) with cerebral hemorrhage. Compared with nonstroke patients, a significantly higher RDW was measured in patients with cerebral stroke and cerebral infarction. However, no significant difference was seen in RDW between patients with cerebral hemorrhage and nonstroke patients. After adjustment by age, hypertension, albumin, Charlson Comorbidity Score, and C-reactive protein in different multivariable Cox regression models, patients with the highest mean RDW quartile had a 2.55-fold (hazard ratio = 3.55; 95% confidence interval: 1.33-9.51) higher risk of developing cerebral infarction relative to those with the lowest mean RDW quartile. RDW was not an independent risk factor for cerebral hemorrhage.

conclusionsIncreased RDW is an independent risk factor of cerebral infarction in hemodialysis patients.

Indexed as

AdultAgedCerebral InfarctionErythrocyte IndicesFemaleHumansKidney Failure, ChronicMaleMiddle AgedRenal Dialysiscerebral infarctionhemodialysisRed blood cell distribution widthrisk factorstroke

Identifiers

PMID29141483
PMCPMC6446144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.