Evidence map›Paper›PMID 29141446›Full record

ArticleArtificial cells, nanomedicine, and biotechnology2018

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way.

Jinyun Zhu, Kai Lu, Ning Zhang, Yun Zhao, Qunchao Ma, Jian Shen, Yinuo Lin, Pingping Xiang, Yaoliang Tang, Xinyang Hu and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial cells, nanomedicine, and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 4 syntheses or guidelines pooled it, 259 citations in OpenAlex.

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121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jinyun Zhua Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Kai Lub Department of Cardiology , Cardiovascular Key Laboratory of Zhejiang Province , Hangzhou , PR China.
Ning Zhanga Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Yun Zhaoa Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Qunchao Maa Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Jian Shena Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Yinuo Lina Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Pingping Xianga Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Yaoliang Tangd Vascular Biology Center, Department of Medicine , Medical College of Georgia/Georgia Regents University , Augusta , GA , USA.
Xinyang Hua Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Jinghai Chena Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Wei Zhua Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Keith A Webstere Department of Molecular and Cellular Pharmacology, Leonard M. Miller School of Medicine , University of Miami , Miami , FL , USA.
Jian'an Wanga Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Hong Yua Department of Cardiology, Second Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , PR China.
Second Affiliated Hospital of Zhejiang University · CNAugusta University · USThird People's Hospital of Huzhou · CNUniversity of Miami · US

Funding

Hypoxia and cardiac stem cell homingR01HL086555 · NHLBI · UNIVERSITY OF CINCINNATI · PI TANG, YAO LIANG · 2008 to 2019
$3.5M
Regulated Therapeutic Angiogenesis: for Ischemic DiseaseR01HL072924 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WEBSTER, KEITH A · 2003 to 2014
$3.2M
Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
NHLBI NIH HHS R01 HL072924NHLBI NIH HHS R01 HL086555NHLBI NIH HHS R01 HL134354NIAMS NIH HHS R01 AR070029
6 · The paper itself

Abstract

Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (Exo

Indexed as

Myocardial InfarctionAnimalsCell HypoxiaCulture Media, ConditionedExosomesMaleMesenchymal Stem CellsMiceMicroRNAsMyocardiumMyocytes, CardiacSphingomyelin PhosphodiesteraseCulture Media, ConditionedMicroRNAsMIRN210 microRNA, humanSmpd3 protein, mouseSphingomyelin PhosphodiesteraseExosomeshypoxiamicroRNA210MSCsmyocardial infarctionnSMase2

Identifiers

PMID29141446
PMCPMC5955787
OpenAlexW2769944691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.