Evidence map›Paper›PMID 29141262›Full record

Observational studyAmerican journal of perinatology2018

Impact of Pregnancy History and 17-Hydroxyprogesterone Caproate on Cervical Cytokines and Matrix Metalloproteinases.

Steve N Caritis, Gary Hankins, Mary Hebert, David M Haas, Mahmoud Ahmed, Hyagriv Simhan, Laura A Haneline, John Harris, Justine Chang, Alyssa Stephenson Famy and 4 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of perinatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Steve N CaritisDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Gary HankinsDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
Mary HebertDepartment of Pharmacy, University of Washington, Seattle, Washington.
David M HaasDepartment of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana.
Mahmoud AhmedDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
Hyagriv SimhanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Laura A HanelineDepartment of Pediatrics, Indiana University, Indianapolis, Indiana.
John HarrisDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Justine ChangDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington.
Alyssa Stephenson FamyDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington.
Patrick YorioDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.
Zhaoxia RenObstetric and Pediatric Pharmacology and Therapeutics Branch, Eunice Shriver National Institute of Child Health and Human Development, National Institutes of Health, Washington.
Mary E D'AltonDepartment of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
Raman VenkataramananDepartment of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Pregnancy and Drug Metabolizing Enzymes and TransportersU10HD047905 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI CARITIS, STEVE N · 2004 to 2014
$9.7M
UW Obstetric-Fetal Pharmacology Research UnitU10HD047892 · NICHD · UNIVERSITY OF WASHINGTON · PI EASTERLING, THOMAS R, HEBERT, MARY F · 2004 to 2014
$9.4M
Obstetric Pharmacology Research Units Network Center at UTMB-GalvestonU10HD047891 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AHMED, MAHMOUD S, HANKINS, GARY D · 2004 to 2014
$9.3M
UTMB OPRC Administrative CoreU54HD047891 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLARK, SHANNON MICHELLE · 2015 to 2019
$4.8M
Indiana PREGMEDU10HD063094 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$4.2M
Optimization of Drug Dosing in Pregnant Women through Research and EducationU54HD047905 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI VENKATARAMANAN, RAMAN · 2015 to 2019
$3.7M
NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR002319NICHD NIH HHS U10 HD047891NICHD NIH HHS U10 HD047892NICHD NIH HHS U10 HD047905NICHD NIH HHS U10 HD063094NICHD NIH HHS U54 HD047891NICHD NIH HHS U54 HD047905
6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate the impact of pregnancy history and 17-hydroxyprogesterone caproate (17-OHPC) treatment on cervical fluid cytokines and matrix metalloproteinases (MMPs). STUDY

designCervical fluid was obtained between 16

resultsAmong women whose earliest prior delivery occurred between 16 and 23 weeks, cervical fluid concentration of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α at baseline were significantly elevated when compared with cervical cytokines of women whose earliest delivery occurred between 32 and 36 weeks (relative risk ratio was 3.37 for IL-6 [95% confidence interval, CI, 1.08-10.53,

conclusionThe cervical fluid of women with a history of an early prior SPTB is characterized by inflammation that is unaffected by 17-OHPC.

Indexed as

17 alpha-Hydroxyprogesterone CaproateAdultBody FluidsCervix UteriCytokinesFemaleGestational AgeHumansMatrix MetalloproteinasesParityPregnancyPremature BirthProspective StudiesUnited StatesYoung Adult17 alpha-Hydroxyprogesterone CaproateCytokinesMatrix Metalloproteinases

Identifiers

PMID29141262
PMCPMC5876094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.