Evidence map›Paper›PMID 29141234›Full record

ArticleStem cell reports2017

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells.

Zhong Liu, Cheng Zhang, Maria Skamagki, Alireza Khodadadi-Jamayran, Wei Zhang, Dexin Kong, Chia-Wei Chang, Jingyang Feng, Xiaosi Han, Tim M Townes and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Cell Cycle Regulation of Stem Cells by MicroRNAs.Stem cell reviews and reports · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Zhong LiuDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Cheng ZhangDepartment of Molecular Pharmacology and Experimental Therapeutics, Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Maria SkamagkiCancer Biology and Genetics Program, Center for Cell Engineering, Center for Stem Cell Biology, Sloan-Kettering Institute, Cell and Developmental Biology Program, Weill Medical College of Cornell University, New York, NY 10065, USA.
Alireza Khodadadi-JamayranDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Wei ZhangDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Dexin KongDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chia-Wei ChangDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jingyang FengCook County Health and Hospital System, John H. Stroger Hospital, Chicago, IL 60612, USA.
Xiaosi HanDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Tim M TownesDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hu LiDepartment of Molecular Pharmacology and Experimental Therapeutics, Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Kitai KimCancer Biology and Genetics Program, Center for Cell Engineering, Center for Stem Cell Biology, Sloan-Kettering Institute, Cell and Developmental Biology Program, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address: kimk@mskcc.org.
Rui ZhaoDepartment of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: ruizhao@uab.edu.
University of Alabama at Birmingham · USCornell University · USMayo Clinic · USJohn H. Stroger, Jr. Hospital of Cook County · US

Funding

A new hypothesis: role of p53 inhibitory factors in cellular reprogrammingR01AG043531 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI KIM, KITAI · 2014 to 2018
$2.3M
Targeting PRMT5 in Cancer Initiating Cells as a New Therapy for GlioblastomaR01NS095626 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HAN, XIAOSI · 2015 to 2019
$1.6M
A network platform to connect drug response and prognosis phenotypes for cancersR01CA196631 · NCI · MAYO CLINIC ROCHESTER · PI LI, HU · 2016 to 2018
$1.2M
Hematopoietic potential of histocompatible embryonic stem cell linesR00HL093212 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI KIM, KITAI · 2012 to 2014
$717k
NCI NIH HHS R01 CA196631NHLBI NIH HHS R00 HL093212NIA NIH HHS R01 AG043531NINDS NIH HHS R01 NS095626
6 · The paper itself

Abstract

Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8

Indexed as

NeurogenesisAnimalsCells, CulturedMiceMicroRNAsNeural Stem CellsPluripotent Stem CellsRibonuclease IIIRNA-Binding ProteinsTumor Suppressor Protein p53Dgcr8 protein, mouseMicroRNAsMIRN302 microRNA, mouseRibonuclease IIIRNA-Binding ProteinsTumor Suppressor Protein p53apoptosisDgcr8differentiationmicroRNAmiR-302neural differentiationnutlin-3ap53pluripotent stem cells

Identifiers

PMID29141234
PMCPMC5688240
OpenAlexW2770073822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.