Evidence map›Paper›PMID 29141222›Full record

ArticleCell reports2017

JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.

Nomeda Girnius, Roger J Davis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. The Duality of Collagens in Metastases of Solid Tumors.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. HER2-driven breast cancer suppression by the JNK signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. The cJUN NHCell death and differentiation · 2018
    Article
  20. The cJUN NHeLife · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nomeda GirniusProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: roger.davis@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698
6 · The paper itself

Abstract

Developmental morphogenesis, tissue injury, and oncogenic transformation can cause the detachment of epithelial cells. These cells are eliminated by a specialized form of apoptosis (anoikis). While the processes that contribute to this form of cell death have been studied, the underlying mechanisms remain unclear. Here, we tested the role of the cJUN NH

Indexed as

AnoikisProtein Processing, Post-TranslationalAnimalsApoptosis Regulatory ProteinsCell LineEpithelial CellsFemaleHumansJNK Mitogen-Activated Protein KinasesMaleMiceMice, Inbred C57BLApoptosis Regulatory ProteinsJNK Mitogen-Activated Protein KinasesanoikisapoptosisBAKBAXBH3-only proteinBIMBMFepithelial cellJNKmammary gland

Identifiers

PMID29141222
PMCPMC5711519
OpenAlexW2771037149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.