ArticleCell reports2017
Th1-like Plasmodium-Specific Memory CD4
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.Antimicrobial agents and chemotherapy · 2022Trial
- Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Memory regulatory T cells reprogram into protective TNature immunology · 2026Article
- Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Cellular and molecular interactions underlying the peripheral immune responses to blood-stage malaria infections.ImmunoHorizons · 2026Review
- Altered natural killer cell function in children with severe malaria.ImmunoHorizons · 2026Article
- Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection.Cell reports · 2025Article
- Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge.ImmunoHorizons · 2025Article
- Gene expression analyses reveal differences in children's response to malaria according to their age.Nature communications · 2024Article
- Cytolytic circumsporozoite-specific memory CD4Nature communications · 2023Article
- Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.Nature communications · 2023Article
- Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy.Nature communications · 2023Article
- Gene expression analyses reveal differences in children's response to malaria according to their age.bioRxiv : the preprint server for biology · 2023Article
- Cellular iron governs the host response to malaria.PLoS pathogens · 2023Article
- ALDH1A Inhibition Suppresses Colitis and Alters α4β7 Integrin Expression on Activated T Cells inNutrients · 2023Article
- Article
- Article
- Review
- Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021Review
- The spleen: "epicenter" in malaria infection and immunity.Journal of leukocyte biology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria. To determine whether Plasmodium-specific Th1- and Tfh-like effector cells generate memory populations that contribute to protection, we developed transgenic parasites that enable high-resolution study of anti-malarial memory CD4 T cells in experimental models. We found that populations of both Th1- and Tfh-like Plasmodium-specific memory CD4 T cells persist. Unexpectedly, Th1-like memory cells exhibit phenotypic and functional features of Tfh cells during recall and provide potent B cell help and protection following transfer, characteristics that are enhanced following ligation of the T cell co-stimulatory receptor OX40. Our findings delineate critical functional attributes of Plasmodium-specific memory CD4 T cells and identify a host-specific factor that can be targeted to improve resolution of acute malaria and provide durable, long-term protection against Plasmodium parasite re-exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.