Evidence map›Paper›PMID 29141185›Full record

ArticleJournal of molecular and cellular cardiology2018

Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium.

Nima Milani-Nejad, Jae-Hoon Chung, Benjamin D Canan, Vadim V Fedorov, Bryan A Whitson, Ahmet Kilic, Peter J Mohler, Paul M L Janssen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nima Milani-NejadDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University Wexner Medical Center, USA.
Jae-Hoon ChungDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University Wexner Medical Center, USA.
Benjamin D CananDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA.
Vadim V FedorovDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA.
Bryan A WhitsonDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, USA.
Ahmet KilicDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, USA.
Peter J MohlerDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, USA.
Paul M L JanssenDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, USA. Electronic address: janssen.10@osu.edu.

Funding

Targeting the Arrhythmogenic Sources of Human Atrial FibrillationR01HL135109 · NHLBI · OHIO STATE UNIVERSITY · PI Vadim V Fedorov · 2017 to 2026
$6.0M
Frequency-dependent modulation of cardiac myofilament function in health/diseaseR01HL113084 · NHLBI · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML · 2012 to 2023
$4.6M
Integration of structure and signaling in cardiac pacemaker functionR01HL115580 · NHLBI · OHIO STATE UNIVERSITY · PI FEDOROV, VADIM V · 2013 to 2021
$4.2M
NHLBI NIH HHS R01 HL113084NHLBI NIH HHS R01 HL115580NHLBI NIH HHS R01 HL135109
6 · The paper itself

Abstract

Cross-bridge attachment allows force generation to occur, and rate of tension redevelopment (k NEWS AND NOTEWORTHY: We show that isolated human myocardium is capable of transiently increasing its maximal force generation capability by increasing cross-bridge recruitment following slack-restretch maneuver. This process can potentially have important implications and significance in cardiac contraction in vivo.

Indexed as

AgedBiomechanical PhenomenaFemaleHumansKineticsMaleMiddle AgedMyocardiumTemperatureCardiac contractionCardiac regulationContractile kineticsCross-bridge cycling rate

Identifiers

PMID29141185
PMCPMC5801127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.