Evidence map›Paper›PMID 29140951›Full record

Observational studyThe journal of trauma and acute care surgery2018

Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.

Farzad Moazed, Carolyn Hendrickson, Mary Nelson, Amanda Conroy, Mitchell J Cohen, Carolyn S Calfee

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of trauma and acute care surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Environmental Factors.Critical care clinics · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Farzad MoazedFrom the Department of Medicine (F.M., C.H., C.S.C.), University of California San Francisco; San Francisco General Hospital (M.N., A.C.), San Francisco, California; Department of Surgery (M.J.C.), University of Colorado, Denver, Colorado; Department of Anesthesia (C.S.C.), University of California San Francisco; Cardiovascular Research Institute (C.S.C.), and Center for Tobacco Control Research and Education (C.S.C.), University of California San Francisco, San Francisco, California.
Carolyn Hendrickson
Mary Nelson
Amanda Conroy
Mitchell J Cohen
Carolyn S Calfee
University of Colorado Denver · USUniversity of California, San Francisco · US

Funding

Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt TraumaR01HL110969 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2012 to 2016
$1.9M
Biomarker Research in Musculoskeleton DiseaseK24AR051895 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAUER, DOUGLAS C · 2005 to 2015
$1.5M
Acute Respiratory Distress Syndrome after Isolated Traumatic Brain Injury: Platelet Biology, Endothelial Activation, and Mechanical VentilationK23HL133495 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDRICKSON, CAROLYN MARIE · 2016 to 2020
$994k
Cigarette smoke and the acute respiratory distress syndrome: mechanisms and the role of alveolar macrophages in primingK23HL136844 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOAZED, FARZAD · 2017 to 2018
$397k
Cigarette Smoke and the Acute Respiratory Distress Syndrome: The Role of Alveolar Epithelial Injury and InflammationF32HL126345 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOAZED, FARZAD · 2015 to 2016
$106k
NCATS NIH HHS KL2 TR001870NHLBI NIH HHS F32 HL126345NHLBI NIH HHS K23 HL133495NHLBI NIH HHS K23 HL136844NHLBI NIH HHS R01 HL110969NIAMS NIH HHS K24 AR051895
6 · The paper itself

Abstract

backgroundThe risk of the acute respiratory distress syndrome (ARDS) is increased in passive and active smokers after blunt trauma. However, the mechanisms responsible, including the role of platelet aggregation, for this association are unknown.

methodsWe analyzed 215 patients with severe blunt trauma from a prospective observational cohort at a Level I trauma center between 2010 and 2015. Subjects underwent impedance-based platelet aggregometry in response to platelet agonists arachidonic acid, adenosine diphosphate, collagen, and thrombin receptor activating peptide-6. Acute respiratory distress syndrome within the first 8 days of admission was adjudicated using Berlin criteria. Plasma cotinine was measured to assess cigarette smoke exposure. Regression analyses were used to assess the relationship between (1) platelet aggregation and ARDS and (2) cigarette smoke exposure and platelet aggregation.

resultsAt both 0 hour and 24 hours, impaired platelet aggregation was associated with increased odds of developing ARDS. Cigarette smoke exposure was associated with increased platelet aggregation upon arrival to the emergency department. However, at 24 hours, cigarette smoke exposure was associated with increased impairment in platelet aggregation, reflecting a statistically significant decline in platelet aggregation over the initial 24 hours after trauma. The relationship between this decline in platelet aggregation and ARDS differed by cigarette smoke exposure status, suggesting that impaired platelet activation differentially affects the risk of ARDS in those with cigarette smoke exposure (arachidonic acid, p for interaction: 0.005, collagen p for interaction: 0.02, adenosine diphosphate, p for interaction: 0.05).

conclusionImpaired platelet aggregation at 0 hour and 24 hours is associated with an increased risk of developing ARDS after severe blunt trauma. Cigarette smoke-exposed patients are more likely to develop impaired platelet aggregation over the first 24 hours of admission, which may contribute to their increased risk of ARDS. LEVEL OF EVIDENCE: Prognostic/Epidemiological, level III.

Indexed as

Trauma CentersAdultBlood PlateletsFemaleFollow-Up StudiesHumansMaleMiddle AgedPlatelet AggregationPlatelet Function TestsProspective StudiesRespiratory Distress SyndromeSmokingTime FactorsWounds, Nonpenetrating

Identifiers

PMID29140951
PMCPMC5780202
OpenAlexW2770725222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.