Evidence map›Paper›PMID 29140443›Full record

Observational studyThe Journal of infectious diseases2018

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users.

Gaby S Steba, Sylvie M Koekkoek, Joost W Vanhommerig, Kees Brinkman, David Kwa, Jan T M Van Der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A Paxton and 3 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility.Liver international : official journal of the International Association for the Study of the Liver · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Gaby S StebaDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Sylvie M KoekkoekDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Joost W VanhommerigDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Kees BrinkmanDepartment of Internal Medicine, Amsterdam, The Netherlands.
David KwaDepartment of Microbiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Jan T M Van Der MeerDepartment of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS, Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands.
Maria PrinsDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Ben BerkhoutDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Michael TanckDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.
William A PaxtonDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Richard MolenkampDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
Janke SchinkelDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
MSM Observational Study of Acute Infection with Hepatitis C (MOSAIC) Study Group and Amsterdam Cohort Studies (ACS)
Academic Medical Center · NLGGD Amsterdam · NLOLVG · NLUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

Indexed as

Genetic Predisposition to DiseaseHomosexuality, MaleAdultCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinGenotypeHepatitis CHumansLectins, C-TypeMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticProspective StudiesReceptors, Cell SurfaceSubstance Abuse, IntravenousCell Adhesion MoleculesCLEC4M protein, humanDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeReceptors, Cell SurfaceDC-SIGNHepatitis C viruslectinsexual transmissionsingle nucleotide polymorphism

Identifiers

PMID29140443
PMCPMC5853896
OpenAlexW2777652517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.