ArticleChildren (Basel, Switzerland)2017
Clinical Profile Associated with Adverse Childhood Experiences: The Advent of Nervous System Dysregulation.
Article in Children (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Parental upheaval experienced in childhood and its effect on pain-related cognitions across the lifespan: an exploratory investigation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Exploration of wearable sensor measures associated with panic attacks differs across mental health conditions.Frontiers in digital health · 2026Article
- The California adverse childhood experiences screening roll-out: a survey study of ACEs screening implementation in primary care.Frontiers in public health · 2025Article
- Heart rate variability and tension-type headache: A population-based cross-sectional study.IBRO neuroscience reports · 2023Article
- Sleep disturbance as transdiagnostic mediator between adverse childhood experiences and psychopathology in children and adolescents: A structural equation modeling meta-analysis.JCPP advances · 2023Article
- Limitations of the protective measure theory in explaining the role of childhood sexual abuse in eating disorders, addictions, and obesity: an updated model with emphasis on biological embedding.Eating and weight disorders : EWD · 2022Review
- Article
- Medically Unexplained Symptoms and Attachment Theory: The BodyMind Approach®.Frontiers in psychology · 2019Article
- Adverse Childhood Experiences in Children with Intellectual Disabilities: An Exploratory Case-File Study in Dutch Residential Care.International journal of environmental research and public health · 2018Article
- From Dysregulation to Coherence: Exploring the HeartMathGlobal advances in integrative medicine and healthArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe report the prevalence of children with multiple medical symptoms in a pediatric neurology clinic, describe their symptom profiles, and explore their association with adverse childhood experiences (ACEs).
methodsWe retrospectively reviewed 100 consecutive patients from an outpatient pediatric neurology clinic. Patients were included if they were ≥5 years old and reported ≥4 symptoms that were unexplained for ≥3-months. Symptom profiles across six functional domains were recorded: (1) executive dysfunction, (2) sleep disturbances, (3) autonomic dysregulation, (4) somatization, (5) digestive symptoms, and (6) emotional dysregulation. ACEs were scored for all patients.
resultsSeventeen patients reported ≥4 medical symptoms. Somatization, sleep disturbances, and emotional dysregulation occurred in 100% patients, with executive dysfunction (94%), autonomic dysregulation (76%), and digestive problems (71%) in the majority. Forty-two children reported ≥1 ACE, but children with ≥4 symptoms were more likely to report ACEs compared to other children (88% vs. 33%;
conclusionsChildren with multiple medical symptoms should be screened for potential exposure to ACEs. A clinical profile of symptoms across multiple functional domains suggests putative neurobiological mechanisms involving stress and nervous system dysregulation that require further study.
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