ArticleeLife2017
Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- PGC-derived migrasomes couple PGC proliferation with migration.Nature communications · 2026Article
- Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.Nature communications · 2025Article
- Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate-wide phylogeny.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Maternal TGF-β ligand Panda breaks the radial symmetry of the sea urchin embryo by antagonizing the Nodal type II receptor ACVRII.PLoS biology · 2024Article
- Optogenetic control of Nodal signaling patterns.bioRxiv : the preprint server for biology · 2024Article
- Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus.eLife · 2024Article
- Advances in research of biological functions of Isthmin-1.Journal of cell communication and signaling · 2023Review
- Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila.Developmental cell · 2023Article
- Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions.BMC genomics · 2022Article
- The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo.Development (Cambridge, England) · 2022Article
- Evolution and loss of ß-catenin and TCF-dependent axis specification in insects.Current opinion in insect science · 2022Review
- Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.Nature communications · 2022Article
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- Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids.Stem cell reports · 2021Article
- BMP heterodimers signal via distinct type I receptor class functions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.Angiogenesis · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Nodal is considered the key inducer of mesendoderm in vertebrate embryos and embryonic stem cells. Other TGF-beta-related signals, such as Vg1/Dvr1/Gdf3, have also been implicated in this process but their roles have been unclear or controversial. Here we report that zebrafish embryos without maternally provided
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.