Evidence map›Paper›PMID 29140250›Full record

ArticleeLife2017

Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning.

Jose L Pelliccia, Granton A Jindal, Rebecca D Burdine

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Interaction Between theInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Optogenetic control of Nodal signaling patterns.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Frontiers in cell and developmental biology · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. BMP heterodimers signal via distinct type I receptor class functions.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jose L PellicciaDepartment of Molecular Biology, Princeton University, Princeton, United States.ORCID http://orcid.org/0000-0002-8452-2126
Granton A JindalDepartment of Molecular Biology, Princeton University, Princeton, United States.ORCID http://orcid.org/0000-0003-2803-9831
Rebecca D BurdineDepartment of Molecular Biology, Princeton University, Princeton, United States.ORCID http://orcid.org/0000-0001-6620-5015
Princeton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Connecting Polycystin Signaling to Asymmetric Nodal ExpressionR01HD048584 · NICHD · PRINCETON UNIVERSITY · PI BURDINE, REBECCA D. · 2007 to 2016
$3.5M
NICHD NIH HHS R01 HD048584NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish;

Indexed as

Body PatterningSignal TransductionAnimalsGerm LayersNodal ProteinTransforming Growth Factor betaZebrafishZebrafish ProteinsGdf3 protein, zebrafishNodal ProteinTransforming Growth Factor betaZebrafish Proteinsdevelopmental biologyGdf3Kupffer's vesicleleft-right patterningmesendodermNodalstem cellsVg1zebrafish

Identifiers

PMID29140250
PMCPMC5745080
OpenAlexW2770478165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.