Evidence map›Paper›PMID 29140249›Full record

ArticleeLife2017

Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish.

Brent W Bisgrove, Yi-Chu Su, H Joseph Yost

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Optogenetic control of Nodal signaling patterns.Development (Cambridge, England) · 2025
    Article
  3. Optogenetic control of Nodal signaling patterns.Development (Cambridge, England) · 2025
    Article
  4. Optogenetic control of Nodal signaling patterns.Development (Cambridge, England) · 2025
    Article
  5. The Interaction Between theInternational journal of molecular sciences · 2025
    Article
  6. Optogenetic control of Nodal signaling patterns.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model.Journal of cardiovascular development and disease · 2021
    Review
  18. Article
  19. BMP heterodimers signal via distinct type I receptor class functions.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brent W BisgroveMolecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, United States.ORCID http://orcid.org/0000-0002-0665-6401
Yi-Chu SuMolecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, United States.ORCID http://orcid.org/0000-0003-1621-6650
H Joseph YostMolecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, United States.ORCID http://orcid.org/0000-0003-2961-5669
University of Utah · US

Funding

Genome-wide Analysis of Cardiac Development in ZebrafishU01HL098160 · NHLBI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2009 to 2014
$8.0M
Genome-Wide Analysis of Cardiac Development in ZebrafishUM1HL098160 · NHLBI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2015 to 2019
$3.7M
NHLBI NIH HHS U01 HL098160NHLBI NIH HHS UM1 HL098160
6 · The paper itself

Abstract

Zebrafish Gdf3 (Dvr1) is a member of the TGFβ superfamily of cell signaling ligands that includes

Indexed as

Body PatterningSignal TransductionAnimalsNodal ProteinTransforming Growth Factor betaZebrafishZebrafish ProteinsGdf3 protein, zebrafishNodal ProteinTransforming Growth Factor betaZebrafish Proteinsaxis formationdevelopmental biologyGdf3Nodalpatterningstem cellsVg1zebrafish

Identifiers

PMID29140249
PMCPMC5745076
OpenAlexW2770342858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.