Evidence map›Paper›PMID 29140236›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Impact of Childhood Nutritional Status on Pathogen Prevalence and Severity of Acute Diarrhea.

Kirkby D Tickell, Patricia B Pavlinac, Grace C John-Stewart, Donna M Denno, Barbra A Richardson, Jaqueline M Naulikha, Ronald K Kirera, Brett E Swierczewski, Benson O Singa, Judd L Walson

Registry-linked trialAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05519254 (Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05519254 phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae

TypeinterventionalSponsorUniversity of WashingtonRan2023 to 2026Enrolled600ConditionsDiarrhea, Wasting, Malnutrition, ChildArmsLactoferrin, Lysozyme, Lactoferrin + Lysozyme, Placebo
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kirkby D TickellUniversity of Washington, Seattle, Washington.
Patricia B PavlinacUniversity of Washington, Seattle, Washington.
Grace C John-StewartUniversity of Washington, Seattle, Washington.
Donna M DennoThe Childhood Acute Illness & Nutrition Network, Nairobi, Kenya.
Barbra A RichardsonUniversity of Washington, Seattle, Washington.
Jaqueline M NaulikhaKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Ronald K KireraUnited States Army Medical Research Directorate-Kenya (USAMD-K), Nairobi, Kenya.
Brett E SwierczewskiUnited States Army Medical Research Directorate-Kenya (USAMD-K), Nairobi, Kenya.
Benson O SingaKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Judd L WalsonThe Childhood Acute Illness & Nutrition Network, Nairobi, Kenya.

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
NIAID NIH HHS T32 AI007140NICHD NIH HHS K24 HD054314
6 · The paper itself

Abstract

Children with acute and chronic malnutrition are at increased risk of morbidity and mortality following a diarrheal episode. To compare diarrheal disease severity and pathogen prevalence among children with and without acute and chronic malnutrition, we conducted a cross-sectional study of human immunodeficiency virus-uninfected Kenyan children aged 6-59 months, who presented with acute diarrhea. Children underwent clinical and anthropometric assessments and provided stool for bacterial and protozoal pathogen detection. Clinical and microbiological features were compared using log binomial regression among children with and without wasting (mid-upper arm circumference ≤ 125 mm) or stunting (height-for-age

Indexed as

Nutritional StatusAcute DiseaseCampylobacterChild Nutritional Physiological PhenomenaChild, PreschoolCross-Sectional StudiesCryptosporidiumDiarrheaEntamoebaEscherichia coliFecesFemaleGiardiaGrowth DisordersHumansInfant

Identifiers

PMID29140236
PMCPMC5817755

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.