Evidence map›Paper›PMID 29140111›Full record

ArticleAIDS research and human retroviruses2017

Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming.

Joshua Chan, Patrick Y Kim, Emiko Kranz, Yoshiko Nagaoka, YooJin Lee, Jing Wen, Heidi J Elsaesser, Meng Qin, David G Brooks, Gene-Errol Ringpis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joshua Chan1 Division of Hematology and Oncology, David Geffen School of Medicine at UCLA , Los Angeles, California.
Patrick Y Kim2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Emiko Kranz2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Yoshiko Nagaoka2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
YooJin Lee2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Jing Wen2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Heidi J Elsaesser2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Meng Qin2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
David G Brooks2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Gene-Errol Ringpis2 Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA , Los Angeles, California.
Irvin S Y Chen1 Division of Hematology and Oncology, David Geffen School of Medicine at UCLA , Los Angeles, California.
Masakazu Kamata1 Division of Hematology and Oncology, David Geffen School of Medicine at UCLA , Los Angeles, California.

Funding

Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Gene-Engineered Stem Cell Memory T-Cells With Anti-HIV Chimeric Antigen ReceptorsR01AI110200 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAMATA, MASAKAZU · 2016 to 2019
$1.5M
NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI110200
6 · The paper itself

Abstract

Cytotoxic T cells are critical in controlling virus infections. However, continuous antigen stimulation and negative regulatory factors cause CD8 T cells to enter a dysfunctional state (T cell exhaustion), resulting in viral persistence. We hypothesized that the exhausted T cell state could be molecularly rejuvenated using a somatic cell reprogramming technology, which is technically able to convert any types of cells to induced pluripotent stem cells (iPSCs), to regenerate functional T cells capable of purging chronic infection. We generated a new mouse line (B6/129

Indexed as

AnimalsCD4-Positive T-LymphocytesCell DifferentiationCellular ReprogrammingDoxycyclineHIV InfectionsHumansInduced Pluripotent Stem CellsKruppel-Like Factor 4Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, TransgenicProof of Concept StudyT-Lymphocytes, CytotoxicDoxycyclineKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4CD8 T cellchronic infectioniPSCLCMVsomatic cell reprogrammingT cell exhaustion

Identifiers

PMID29140111
PMCPMC5684681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.