ReviewNature reviews. Gastroenterology & hepatology2017
Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.
Review in Nature reviews. Gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Non-invasive fluorescence sensing reveals changes in intestinal barrier function and gastric emptying rate in a first-in-human study of Crohn's disease.Therapeutic advances in gastroenterology · 2025Article
- Self-Supervised Joint Learning for pCLE Image Denoising.Sensors (Basel, Switzerland) · 2024Article
- Transcutaneous fluorescence spectroscopy: development and characterization of a compact, portable, and fiber-optic sensor.Journal of biomedical optics · 2024Article
- Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy.Nature reviews. Gastroenterology & hepatology · 2023Review
- Gut microbiome development and childhood undernutrition.Cell host & microbe · 2022Review
- Article
- Towards Intraoperative Quantification of Atrial Fibrosis Using Light-Scattering Spectroscopy and Convolutional Neural Networks.Sensors (Basel, Switzerland) · 2021Article
- Plasmonic optical fiber for bacteria manipulation-characterization and visualization of accumulation behavior under plasmo-thermal trapping.Biomedical optics express · 2021Article
- Review
- Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences.Scientific reports · 2020Article
- Endoneering: A new perspective for basic research in gastrointestinal endoscopy.United European gastroenterology journal · 2020Article
- Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies.BMC medicine · 2019Review
- Gastrointestinal diagnosis using non-white light imaging capsule endoscopy.Nature reviews. Gastroenterology & hepatology · 2019Review
- EB 2017 Article: Interpretation of the lactulose:mannitol test in rural Malawian children at risk for perturbations in intestinal permeability.Experimental biology and medicine (Maywood, N.J.) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 10 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.